Results 21 to 30 of about 22,678 (88)

β2-Adrenergic Receptor-Mediated Histamine H1 Receptor Down-Regulation: Another Possible Advantage of β2 Agonists in Asthmatic Therapy

Journal of Pharmacological Sciences, 2004
To clarify heterologous regulation of a receptor is important in considering medication. Histamine constricts the airway smooth muscle through the action to the H1 receptor (H1R), which contributes to asthma.
Nozomi Kawakami, Katsuhiro Miyoshi, Shuhei Horio, Hiroyuki Fukui   +3 more
doaj   +1 more source

MAPK Regulation of Sclerotial Development in Sclerotinia sclerotiorum Is Linked with pH and cAMP Sensing

Molecular Plant-Microbe Interactions, 2004
Sclerotial development is fundamental to the disease cycle of the omnivorous broad host range fungal phytopathogen Sclerotinia sclerotiorum. We have isolated a highly conserved homolog of ERK-type mitogen-activated protein kinases (MAPKs) from S ...
Changbin Chen, Arye Harel, Rena Gorovoits, Oded Yarden, Martin B. Dickman   +4 more
doaj   +1 more source

Kinase signalling adaptation supports dysfunctional mitochondria in disease

Frontiers in Molecular Biosciences
Mitochondria form a critical control nexus which are essential for maintaining correct tissue homeostasis. An increasing number of studies have identified dysregulation of mitochondria as a driver in cancer.
George L. Skalka, Mina Tsakovska, Daniel J. Murphy, Daniel J. Murphy   +3 more
doaj   +1 more source

Phosphorylation-mediated Activation and Translocation of the Cyclic AMP-specific Phosphodiesterase PDE4D3 by Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinases

Journal of Biological Chemistry, 1999
In this study, we describe a novel mechanism by which a protein kinase C (PKC)-mediated activation of the Raf-extracellular signal-regulated kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) cascade regulates the activity and membrane ...
Hanguan Liu, D. Maurice
semanticscholar   +1 more source

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A

mSphere, 2017
Protein kinases are key regulators of signal transduction pathways that participate in diverse cellular processes. In fungal pathogens, kinases regulate signaling pathways that govern drug resistance, stress adaptation, and pathogenesis.
Jinglin L. Xie, Teresa R. O’Meara, Elizabeth J. Polvi, Nicole Robbins, Leah E. Cowen   +4 more
doaj   +1 more source

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells

Scientific Reports, 2018
β-cell proliferation induction is a promising therapeutic strategy to restore β-cell mass. By screening small molecules in a transgenic zebrafish model of type 1 diabetes, we identified inhibitors of non-canonical IκB kinases (IKKs), TANK-binding kinase ...
Jin Xu, Yun-Fang Jia, Subhasish Tapadar, Jessica D. Weaver, Idris O. Raji, Deeti J. Pithadia, Naureen Javeed, Andrés J. García, Doo-Sup Choi, Aleksey V. Matveyenko, Adegboyega K. Oyelere, Chong Hyun Shin   +11 more
doaj   +1 more source

Transient Activation of Cyclic AMP-dependent Protein Kinase during Hippocampal Long-term Potentiation*

Journal of Biological Chemistry, 1996
Long-term potentiation (LTP) in the hippocampus is a possible mechanism for mammalian learning and memory in which protein kinases play critical roles. We have investigated the involvement of cyclic AMP-dependent protein kinase (PKA) in LTP by directly ...
E. Roberson, David Sweatt
semanticscholar   +1 more source

Cyclic AMP-dependent Protein Kinase Phosphorylates Merlin at Serine 518 Independently of p21-activated Kinase and Promotes Merlin-Ezrin Heterodimerization*

Journal of Biological Chemistry, 2004
Mutations in the NF2 tumor suppressor gene encoding merlin induce the development of tumors of the nervous system. Merlin is highly homologous to the ERM (ezrin-radixin-moesin) family of membrane/cytoskeleton linker proteins.
K. Alfthan, L. Heiska, M. Grönholm, G. Renkema, O. Carpén   +4 more
semanticscholar   +1 more source

A systematic review of p53 regulation of oxidative stress in skeletal muscle

Redox Report, 2018
Background: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration.
Kaitlyn Beyfuss, David A. Hood
doaj   +1 more source

Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors.

Biochemical Journal, 1983
D. Glass
semanticscholar   +1 more source