Results 41 to 50 of about 87,184 (381)

A guanosine 5′-triphosphate-dependent protein kinase is localized in the outer envelope membrane of pea chloroplasts [PDF]

, 1988
A guanosine 5-triphosphate (GTP)-dependent protein kinase was detected in preparations of outer chloroplast envelope membranes of pea (Pisum sativum L.) chloroplasts.
A.M. Edelman, A.R. Ashton, C. foyer, C. Schindler, C.V.C. Glover, D.J. Arnon, F.A. Ventimiglia, G.E. Lienhard, G.M. Hathaway, G.M. Hathaway, G.M. Hathaway, H. Erdmann, H. Hidaka, J. Joyard, J. Soll, J. Soll, J. Soll, J. Soll, J.F. Allen, J.F. Kuo, J.G. Chafouleas, K. Birkenhead, K. Cline, K. Keegstra, P. Bhalla, R. Ranjeva, R.A. Douce, R.J.H. Budde, S. Gowda, S. Murakami, S.J. Coughlan, T.F.J. Yan, U.K. Laemmli, W.A. Laing, Z.F. Lin   +34 more
core   +1 more source

A Cyclic AMP-Dependent Protein Kinase of the Bovine Pineal Gland [PDF]

Proceedings of the National Academy of Sciences, 1971
A protein kinase that is dependent on cAMP was found to be present in significant amounts in rat and bovine pineal glands. This enzyme system was isolated from bovine pineal glands and shown to consist of two proteins, a kinase and a cAMP-binding protein.
Walter Lovenberg, Joseph A. Fontana
openaire   +3 more sources

Kinase signalling adaptation supports dysfunctional mitochondria in disease

Frontiers in Molecular Biosciences
Mitochondria form a critical control nexus which are essential for maintaining correct tissue homeostasis. An increasing number of studies have identified dysregulation of mitochondria as a driver in cancer.
George L. Skalka, Mina Tsakovska, Daniel J. Murphy, Daniel J. Murphy   +3 more
doaj   +1 more source

Phosphorylation-mediated Activation and Translocation of the Cyclic AMP-specific Phosphodiesterase PDE4D3 by Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinases

Journal of Biological Chemistry, 1999
In this study, we describe a novel mechanism by which a protein kinase C (PKC)-mediated activation of the Raf-extracellular signal-regulated kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) cascade regulates the activity and membrane ...
Hanguan Liu, D. Maurice
semanticscholar   +1 more source

Phosphoproteins associated with cyclic nucleotide stimulation of ciliary motility in Paramecium [PDF]

, 1990
Permeabilized, MgATP-reactivated cells of Paramecium (models) respond to cyclic AMP and cyclic GMP by increasing forward swimming speed. In association with the motile response, cyclic AMP and 8-bromo-cyclic GMP (8-Br-cyclic GMP) stimulated protein ...
Bonini, Nancy M., Nelson, David L.
core  

Caffeine Inhibits EGF-Stimulated Trophoblast Cell Motility through the Inhibition of mTORC2 and Akt. [PDF]

, 2012
Impaired trophoblast invasion is associated with pregnancy disorders such as early pregnancy loss and preeclampsia. There is evidence to suggest that the consumption of caffeine during pregnancy may increase the risk of pregnancy loss; however, little is
Alison E. Wallace, Bauer, Beavo, Biadasiewicz, Boulbes, Brent, Brooke Lumicisi, Brosens, Burton, CARE Study Group, Cartwright, Cartwright, Cartwright, Chui, Di Fiore, Fabro, Foukas, Goldstein, Gude, Guy S. Whitley, Hofmann, Isobelle Grant, Jang, Judith E. Cartwright, Julien, LaMarca, LaMarca, LaMarca, Lee, Liu, Marone, Maslova, Mei, Olayioye, Omori, Pollheimer, Robertson, Spindle, Stefanidou, Tsygankova, Wadge, Weng, Yarden, Yarden, Yoshino, Zhang, Zoncu   +46 more
core   +1 more source

Engineering a bioluminescent indicator for cyclic AMP-dependent protein kinase [PDF]

Biochemical Journal, 1991
cDNA coding for the luciferase in the firefly Photinus pyralis was amplified in vitro to generate cyclic AMP-dependent protein kinase phosphorylation sites. The DNA was transcribed and translated to generate light-emitting protein. A valine at position 217 was mutated to arginine to generate a site RRFS and the heptapeptide kemptide, the ...
Graciela B. Sala-Newby, Anthony K. Campbell   +1 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Experimental approaches to understanding the role of protein phosphorylation in the regulation of neuronal function [PDF]

, 1983
Studies by Earl Sutherland and his colleagues on hormonal regulation of the breakdown of glycogen in liver resulted in the discovery that the first step in the action of many hormones is to increase the synthesis of cAMP by activating adenylate cyclase ...
Kennedy, Mary B.
core  

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]

, 1994
Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core   +2 more sources