Results 251 to 260 of about 986,227 (410)
Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao+12 more
wiley +1 more source
Studies on the Mechanism of Action of the Inhibitory Effect of Prostaglandin F2α on Cyclic AMP Accumulation in Rat Corpora Lutea of Various Ages1 [PDF]
M. Iqbal Khan+6 more
openalex +1 more source
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu+16 more
wiley +1 more source
Cyclic AMP and the induction of eukaryotic gene transcription.
J. William+6 more
semanticscholar +1 more source
Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion
This study identifies Globo H ceramide (GHCer) as a novel immune checkpoint molecule that suppresses the activation of conventional T lymphocytes while promoting the differentiation and function of regulatory T cells. The immunosuppressive effects of GHCer are mediated through the activation of the A2AR/cAMP/PKA pathway, which involves its interactions
Jing‐Yan Cheng+13 more
wiley +1 more source
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang+11 more
wiley +1 more source
Abnormal Calcium Handling in Atrial Fibrillation Is Linked to Changes in Cyclic AMP Dependent Signaling. [PDF]
Reinhardt F+6 more
europepmc +1 more source
Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats. [PDF]
Alexander Rabinovitch+3 more
openalex +1 more source