Results 301 to 310 of about 233,579 (364)

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

Advanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong, Changyu Shang, Jinhong Gu, Huilin Tao, Xuemei Lu, Jin Hou, Zhiyong Cui, Qingsheng Qi   +7 more
wiley   +1 more source

Industrial Alkaline Electrolyzers Enabled by Interface‐Engineered Cobalt Oxide Electrodes for High‐Efficiency Water Splitting

Advanced Science, EarlyView.
Alkaline electrolysis is an important means to generate green hydrogen from water splitting, and its technical advance hinges critically on the breakthrough of catalytic electrodes capable of high current densities at low overpotentials. Here cobalt oxide electrodes engineered with metal cobalt transition layers are developed to assemble an industrial ...
Cheng Li, Xuyu Luo, Ying Wang, Mingze Zhu, Dan Li, Shiying Guo, Wei Wang, Xiaoyong Xu   +7 more
wiley   +1 more source

Dead or alive: how the immune system detects microbial viability

, 2019
Sander, L., Ugolini, M.
core   +1 more source

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Urinary cyclic AMP in vitamin D deficiency rickets

The Turkish Journal of Pediatrics, 1983
N Yordam, G Ciliv, U Saatçi, S Ozsoylu
doaj  

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Cyclic AMP

International Journal of Oral Surgery, 1978
Cyclic AMP mediates the effects of many hormones on their target cells. Some of the mechanisms by which this occurs are discussed in this review. The role of cyclic AMP in regulating glycogen metabolism in liver and skeletal muscle is firmly established.
D, Coppe, M L, Steer
openaire   +2 more sources

Cyclic AMP signalling

Journal of Cell Science, 2001
![Figure][1] Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first identified second messenger. A large number of studies during the past 30 years have elucidated the fundamental role of cAMP in the cellular response to many hormones and neurotransmitters.
FIMIA GM, SASSONE-CORSI P
openaire   +5 more sources

Cyclic AMP in Metobolism

Nature New Biology, 1971
Throughout the animal kingdom cyclic AMP is involved in the regulation of enzyme activity under the influence of hormones. As this review shows, a few clues are beginning to emerge about the way in which this is being achieved.
Ira Pastan, Robert L. Perlman
openaire   +3 more sources

Altered cyclic AMP-binding and db cyclic AMP-unresponsiveness in vivo [PDF]

Nature, 1977
CYCLIC AMP has been implicated in the regulation of cell growth. However, the molecular mechanism of cyclic AMP action, especially that involving the control of tumour growth in vivo is not clear. Our previous studies on two cell populations of Walker 256 mammary carcinoma (W256), one regressing (responsive), the other growing (unresponsive) under ...
Timothy Clair, Yoon S. Cho-Chung
openaire   +2 more sources