Results 301 to 310 of about 986,227 (410)

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

The hepatic glucose-mobilizing effect of glucagon is not mediated by cyclic AMP most of the time.

Am J Physiol Endocrinol Metab, 2021
Rodgers RL.
europepmc   +1 more source

Autophosphorylation of rabbit skeletal muscle cyclic AMP-dependent protein kinase I catalytic subunit.

, 1978
Yu‐Fang Chiu, Minli Tao
openalex   +1 more source

Cyclic di‐AMP mediates biofilm formation

Molecular Microbiology, 2016
X. Peng, Yang Zhang, G. Bai, Xuedong Zhou, Hui Wu   +4 more
semanticscholar   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Synthesis of collagen by chondrocytes in suspension culture: Modulation by calcium, 3′:5′-cyclic AMP, and prostaglandins

, 1977
Kalindi Deshmukh, Barry D. Sawyer
openalex   +1 more source

Cyclic AMP-mediated cyst expansion.

Biochimica et Biophysica Acta, 2011
D. Wallace
semanticscholar   +1 more source

Self‐Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐propelled nanomedicine delivery system forms DMCU nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease‐driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti‐bladder cancer ...
Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu   +9 more
wiley   +1 more source

Protected Chaos in a Topological Lattice

Advanced Science, EarlyView.
Topological and chaotic dynamics are often considered incompatible, with one expected to dominate or disrupt the other. This work reveals that topological localization can persist even under strong chaotic dynamics and, counter‐intuitively, protect chaotic behavior.
Haydar Sahin, Hakan Akgün, Zhuo Bin Siu, S. M. Rafi‐Ul‐Islam, Jian Feng Kong, Mansoor B. A. Jalil, Ching Hua Lee   +6 more
wiley   +1 more source

Genome-wide binding of the cyclic AMP receptor protein in EnteroaggregativeEscherichia colisuggests a role in modulating virulence

Alhammadi MM, Hothersall J, Lloyd GS, Titman SV, Guest T, Browning DF, Grainger DC, Busby SJ, Haycocks JR.   +8 more
europepmc   +1 more source