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The occurrence of cyclic AMP in archaebacteria
Biochemical and Biophysical Research Communications, 1986Cyclic AMP was found in species representative of the three major groups of the archaebacteria. In Methanobacterium thermoautotrophicum starvation for H2 led to a significant increase in cellular cAMP. The findings suggest that the occurrence of cAMP antedates the divergence of the major kingdoms of biology; the observations also imply that cAMP ...
Howard V. Rickenberg +4 more
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1976
Microtubules, tubular structures of 240 A diameter, are widely distributed in plant and animal cells (for a review see (1)). These organelles are present in different sites of the cell; they make up the spindle fibres of the mitotic cells and they are prominent in the axons and dendrites of neurons.
Lydie Rappaport +2 more
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Microtubules, tubular structures of 240 A diameter, are widely distributed in plant and animal cells (for a review see (1)). These organelles are present in different sites of the cell; they make up the spindle fibres of the mitotic cells and they are prominent in the axons and dendrites of neurons.
Lydie Rappaport +2 more
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Cyclic AMP Signaling in Trypanosomatids
Parasitology Today, 2000Curative interference with signal transduction pathways is a spectacularly successful concept in many domains of modern pharmacology; indeed, the 'wonder drug' Viagra is but a humble inhibitor of a cyclic GMP (cGMP)-specific phosphodiesterase and, thus, interferes with cGMP-signaling in a strategic organ.
T Seebeck, C Naula
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On the Biological Role of Cyclic AMP
JAMA: The Journal of the American Medical Association, 1970Before discussing the role of cyclicadenylate, or adenosine 3′,5′-monophosphate (cyclic AMP) in biology, I would like to make a few brief remarks about another subject, the role of the basic scientist in medicine. I would like to hope that this and the subject that I have been asked to write about are not completely unrelated.
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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Cell, 1989G. A. Gonzalez, M. Montminy
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From Epinephrine to Cyclic AMP
Science, 1988Binding of catecholamines to the β-adrenergic receptor results in the activation of adenylate cyclase and the intracellular formation of adenosine 3′,5′-monophosphate (cAMP). In the past 20 years the events that lead from hormone binding at the cell surface receptor site to the synthesis of cAMP at the inner layer of the membrane have been
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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
Nature, 1998J. Rooij +6 more
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, 1976 Fibroblasts grown in monolayer on Petri dishes display various characteristics some of which help one to differentiate normal from malignant cells. For example, malignant fibroblasts, also called “transformed” cells, usually grow faster than their normal counterpart, they do not show density-dependent inhibition of growth, they move more rapidly ...
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CYCLIC AMP AND INSULIN RELEASE
Acta Paediatrica, 1977Abstract. The role of cyclic adenosine‐3′,5′‐monophosphate (CAMP) for insulin secretion has been investigated. In isolated islets of Langerhans from the rat, glucose increases cAMP concomitant with insulin secretion. Stimulation of these two parameters is likewise reversible in parallel. The minimal and maximal concentrations of glucose eliciting CAMP
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