iMetaOmics, EarlyView.This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu +8 more
wiley +1 more source
Cyclic AMP Response Element-binding Protein H (CREBH) Mediates the Inhibitory Actions of Tumor Necrosis Factor α in Osteoblast Differentiation by Stimulating Smad1 Degradation. [PDF]
J Biol Chem, 2015 Jang WG +8 more
europepmc +1 more source
Synthetic biology for medical biomaterials
Interdisciplinary Medicine, EarlyView.Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu +4 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang +12 more
wiley +1 more source
The cyclic AMP response element-binding protein (CREB) mediates smooth muscle cell proliferation in response to angiotensin II. [PDF]
J Cell Commun Signal, 2014 Molnar P +3 more
europepmc +1 more source
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of cerebral ischemia rats and improves behavioral deficits. [PDF]
Neuropsychiatr Dis Treat, 2015 Zhao Y, Xiao M, He W, Cai Z.
europepmc +1 more source
Roles of nanomagnetic beads on biosensing: From fabrication to application
Interdisciplinary Medicine, EarlyView.Leveraging their intrinsic superparamagnetic properties and rapid magnetic responsiveness, functionalized nanomagnetic beads have emerged as pivotal platforms in advanced biosensing system. Through surface engineering and structural design, these magnetic nanoparticles demonstrate multi‐capabilities, such as sample separation, signal enhancement, and ...
Junjie Li +11 more
wiley +1 more source
Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. [PDF]
J Biol Chem, 2013 Almenar-Queralt A +6 more
europepmc +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source