Results 131 to 140 of about 30,015 (162)
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The Journal of Immunology, 1997
Abstract The NF-kappaB family of transcription factors regulates the inducible expression of a variety of genes. Recently, we showed that elevation of intracellular cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytes and endothelial cells without preventing nuclear translocation of NF-kappaB complexes.
G C, Parry, N, Mackman
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Abstract The NF-kappaB family of transcription factors regulates the inducible expression of a variety of genes. Recently, we showed that elevation of intracellular cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytes and endothelial cells without preventing nuclear translocation of NF-kappaB complexes.
G C, Parry, N, Mackman
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CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes.
The Journal of Immunology, 1997Abstract Cyclic AMP-responsive element binding protein (CREB) mediates gene expression in response to cAMP stimulation. The transcriptional activity of CREB depends on both the phosphorylation of Ser133 and the recruitment of cofactor for assembly of transcriptional complex.
Y P, Hsueh +3 more
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Journal of Neurochemistry, 1996
Abstract: We have recently demonstrated that mRNA expression of cyclic AMP (cAMP) response element‐binding protein (CREB) is down‐regulated in CATH.a cells (a neural‐derived cell line) by activation of the cAMP pathway. We now demonstrate that this down‐regulation can be accounted for by a decrease in the rate of CREB gene transcription.
K L, Widnell +6 more
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Abstract: We have recently demonstrated that mRNA expression of cyclic AMP (cAMP) response element‐binding protein (CREB) is down‐regulated in CATH.a cells (a neural‐derived cell line) by activation of the cAMP pathway. We now demonstrate that this down‐regulation can be accounted for by a decrease in the rate of CREB gene transcription.
K L, Widnell +6 more
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Neuroscience, 1999
Previous studies from our laboratory have demonstrated that stimulation of 5-hydroxytryptamine2A receptors in rat cerebellar granule cells produces an increase in the levels of 5-hydroxytryptamine2A receptor messenger RNA and binding sites, and that this up-regulation requires de novo RNA and protein synthesis.
E, Chalecka-Franaszek +2 more
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Previous studies from our laboratory have demonstrated that stimulation of 5-hydroxytryptamine2A receptors in rat cerebellar granule cells produces an increase in the levels of 5-hydroxytryptamine2A receptor messenger RNA and binding sites, and that this up-regulation requires de novo RNA and protein synthesis.
E, Chalecka-Franaszek +2 more
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Journal of Molecular Neuroscience, 2001
Cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that has been implicated in neuronal responses to ischemia. We examined the effect of global cerebral ischemia in the rat on the expression of CREB, its transcriptionally active phosphorylated form (pCREB), and the nuclear adaptor protein, CREB binding protein (CBP ...
K, Jin +3 more
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Cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that has been implicated in neuronal responses to ischemia. We examined the effect of global cerebral ischemia in the rat on the expression of CREB, its transcriptionally active phosphorylated form (pCREB), and the nuclear adaptor protein, CREB binding protein (CBP ...
K, Jin +3 more
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2004
Publisher Summary This chapter discusses identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis. A functional role for the cyclic AMP response element-binding protein (CREB) is demonstrated in controlling gene expression in hypoxia.
Martin O, Leonard +3 more
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Publisher Summary This chapter discusses identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis. A functional role for the cyclic AMP response element-binding protein (CREB) is demonstrated in controlling gene expression in hypoxia.
Martin O, Leonard +3 more
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Activation of cyclic AMP response element-binding protein (CREB) in aggressive periodontal disease.
Quintessence international (Berlin, Germany : 1985), 2011To report a novel observation of neutrophil signal transduction abnormalities in patients with localized aggressive periodontitis (LAP) that are associated with an enhanced phosphorylation of the nuclear signal transduction protein cyclic AMP response element-binding factor (CREB).Peripheral venous blood neutrophils of 18 subjects, 9 patients with LAP ...
Rainer, Buchmann +2 more
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Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020Claudio Hetz +2 more
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Nature Reviews Molecular Cell Biology, 2021Simon Alberti, Anthony A Hyman
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The mechanisms of integral membrane protein biogenesis
Nature Reviews Molecular Cell Biology, 2021Ramanujan Shankar Hegde, Robert J Keenan
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