Results 141 to 150 of about 58,029 (251)

Gramicidin and chlorhexidine encapsulated in bicontinuous microemulsions: Antimicrobial activity performance and their impact on self‐assembly

Journal of Surfactants and Detergents, EarlyView.
Interaction of gramicidin D (gD) and chlorhexidine (CH) with the surfactant monolayers of bicontinuous microemulsions. Abstract The utility of bicontinuous microemulsions (BMEs) as carriers of the antimicrobial peptide (AMP) gramicidin D and antiseptic chlorhexidine was investigated for possible topical delivery to chronic wounds.
Douglas G. Hayes, Riley Arp, Doris H. D'Souza, Manjula Senanayake, Wellington C. Leite, Sai Venkatesh Pingali, Volker S. Urban   +6 more
wiley   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Review 1 - Nature (Busby) [PDF]

, 2009
Scarlato, Vincenzo
core  

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. [PDF]

Cell Cycle, 2014
Zhang R, Misra V.
europepmc   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

Medicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain, Wajiha Arif, Sharjeel Humayun, Nida Shoaib, Saim Mahmood Khan   +4 more
wiley   +1 more source

Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation. [PDF]

Int J Neuropsychopharmacol
Guo TY, Zhang M, Lv YL, Qiu NZ, Chen RM, Zhang FF, Chen W, Zhang F, Gao YF, Wang XD, Zhang XH, Chen MH, Zhang HT, Wang H.   +13 more
europepmc   +1 more source

Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet‐Induced Obese Rats

Molecular Nutrition &Food Research, EarlyView.
Resveratrol improves hypothalamic leptin sensitivity and prevents body weight gain in obese animals, while mitigating adipocyte hypertrophy and promoting adipocyte hyperplasia in the retroperitoneal fat depot. ABSTRACT In obesity, increased adipocyte size is associated with metabolic complications, while elevated adipocyte numbers are considered a ...
Maria Ibars‐Serra, Aïda Pascual‐Serrano, Andrea Ardid‐Ruiz, Núria Doladé, Sonia Aguilar‐González, Julieta Cirasino, Begoña Muguerza, Manuel Suárez, Jaap Keijer, Anna Arola‐Arnal, Gerard Aragonès   +10 more
wiley   +1 more source

Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations. [PDF]

Microbiol Spectr
Gu X, Xiong C, Wang X, Zhu H, Sun W, He Y, Zhang J.   +6 more
europepmc   +1 more source

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Neuroprotection, EarlyView.
Downregulation of the expression of silent information regulator sirtuin 1 (SIRT1) exacerbates neuronal degeneration and loss by activating forkhead box O1 (FOXO1) acetylation and promoting endoplasmic reticulum stress (ERSA)‐mediated apoptosis in aging.
Nan Zhang, Zongyuan Zhao, Xiaoxiao Chen, Hanbing Yao, Min Zhu, Shuqing Ma, Hui Wang, Xianghong Yin, Ying Zhou, Chenfei Zheng, Jianmin Li, Jingye Pan, Kaicheng Wang, Bin Yang, Yunting Wang, Junming Fan, Yongsheng Gong, Rong Liu, Jing Zeng, Xiaofang Fan, Yangping Shentu   +20 more
wiley   +1 more source