Results 191 to 200 of about 58,029 (251)

Decoding the Role of CDCA Genes in Breast Cancer Progression: Insights From in Silico and Functional Assay

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Investigating the diagnostic potential and functional role of CDCA genes in breast cancer. ABSTRACT Background The cell division cycle‐associated (CDCA) genes regulate key cellular processes like cell cycle progression and division. This study evaluates the diagnostic and clinical relevance of CDCA genes in breast cancer.
Yongsheng Zhao, Xiaocha Ma, Jun Zhou
wiley   +1 more source

NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease. [PDF]

World J Gastroenterol
Wang Y, Li GW, Zhu SL, Xu TT, Qin YW, Cheng CQ, Zheng QW, He C, Zhou BD, Fang SQ.   +9 more
europepmc   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Berberine-induced browning and energy metabolism: mechanisms and implications. [PDF]

PeerJ
Alpaslan Ağaçdiken A, Göktaş Z.
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Is GCR1 the GPR157 of plants? [PDF]

Plant Physiol
Gotkhindikar A, Chakravorty D, Sengupta D, Joshi M, Assmann SM.   +4 more
europepmc   +1 more source

Extracellular Vesicles miRNome Profiling Reveals miRNAs Engagement in Dysfunctional Lipid Metabolism, Chronic Inflammation and Liver Damage in Subjects With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
This study explores the association between the miRNome profile of circulating extracellular vesicles and metabolic dysfunction, liver inflammation, and damage in patients with metabolic MASLD, identifying key miRNAs (miR‐122‐5p, miR‐375‐3p, let‐7d‐5p, and let‐7f‐5p) that modulate lipid metabolism and inflammatory pathways in ‘at‐risk MASH’ patients ...
Gian Paolo Caviglia, Elisabetta Casalone, Chiara Rosso, Serena Aneli, Alessandra Allione, Fabrizia Carli, Cristina Grange, Angelo Armandi, Chiara Catalano, Giovanni Birolo, Beatrice Foglia, Davide Giuseppe Ribaldone, Amalia Gastaldelli, Giuseppe Matullo, Elisabetta Bugianesi   +14 more
wiley   +1 more source

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation. [PDF]

J Transl Med
Xiao R, Xu P, Li X, Shen F, Tao S, Zhu X, Cai Y, Feng Z, Liu Z, Xiao H, Ding F, Zhu M.   +11 more
europepmc   +1 more source

Comprehensive computational strategies for multi-target drug discovery in inflammatory bowel disease utilizing bioactive compounds. [PDF]

Sci Rep
Mansouri P, Mansouri P, Najafipour S, Kouhpayeh SA, Farjadfar A, Behmard E.   +5 more
europepmc   +1 more source