Results 71 to 80 of about 20,142 (297)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analysis of permeability evolution law of gas-bearing coal under cyclic loading condition
Meitan kexue jishuIn order to explore the permeability evolution law of gas-bearing coal under different cyclic loading and unloading conditions, raw coal samples were taken as the research object, and cyclic loading-unloading experiments of gas-bearing coal were designed
Dengke WANG +8 more
doaj +1 more source
Liquefaction Characteristics of Sand With Polypropylene Fiber at Low Confining Stress
Frontiers in Built Environment, 2020 The present study evaluates the liquefaction characteristics of Ottawa sand with polypropylene fiber using cyclic triaxial test. A series of stress-controlled cyclic triaxial tests were performed at 34.47 kPa (5 psi) effective confining pressure ...
Sudhir K. Tripathi +3 more
doaj +1 more source
Brushes of semiflexible polymers in equilibrium and under flow in super-hydrophobic regime [PDF]
, 2015 We performed molecular dynamics simulations to study equilibrium and flow properties of a liquid in a nano-channel with confining surfaces coated with a layer of grafted semiflexible polymers.
Pastorino, Claudio, Speyer, Kevin
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Advances in Civil EngineeringThe research work aimed at identifying the failure mode and energy evolution of damaged granite by uniaxial compression tests. The predamage specimens were prepared by cyclic loading with high confining pressure under constant upper and lower cyclic ...
Yabin Wu, Xiaosheng Liu
doaj +1 more source
Resilient Modulus Characterization of Alaskan Granular Base Materials [PDF]
, 2010 INE/AUC 11 ...
Li, Lin, Liu, Juanyu, Zhang, Xiong
core
Regional Flow Simulation in Fractured Aquifers Using Stress-Dependent Parameters [PDF]
, 2011 A model function relating effective stress to fracture permeability is developed from Hooke's law, implemented in the tensorial form of Darcy's law, and used to evaluate discharge rates and pressure distributions at regional scales.
Abaqus. +25 more
core +3 more sources