Results 81 to 90 of about 20,015 (278)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Undrained deformation characteristic of saturated soft clay under traffic loading

Shuiwen dizhi gongcheng dizhi
Previous studies on the undrained deformation behavior of saturated soft clay under traffic loading usually ignored the effect of cyclic confining pressure.
Lei SUN, Yuke WANG
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dynamic Properties of Compacted Cohesive Soil Based On Resonant Column Studies [PDF]

, 2015
Dynamic properties of compacted cohesive soils are required in most of the civil engineering constructions. These include construction of dams, dikes, embankments, liners and levees.
Dutta, T T, Saride, Sireesh
core  

Numerical model for CFRP confined concrete elements subject to monotonic and cyclic loadings [PDF]

, 2009
Uniaxial cyclic and monotonic compression tests were carried out on partially and fully wrapped concrete cylinders with Carbon Fibre Reinforced Polymer (CFRP) wet lay-up sheets.
Barros, Joaquim A. O., Sena-Cruz, José, Varma, R. K.   +2 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Prediction of pile response to lateral spreading by 3-D soil-water coupled dynamic analysis: shaking in the direction of ground flow [PDF]

, 2008
Numerical predictions of a series of shake table tests are presented in this paper in order to examine the accuracy of a 3-D effective stress analysis in predicting the behavior of piles subjected to liquefaction-induced ground flow.
Cubrinovski, M., Ishihara, K., Kamata, T., Sato, M., Sugita, H., Tokimatsu, K., Tsukamoto, Y., Uzuoka, R.   +7 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Mechanism of Structural Damage in Low Permeability Coal Material of Coalbed Methane Reservoir under Cyclic Cold Loading

Energies, 2020
The pore and fracture structure of coal is the main factor that affects the storage and seepage capacity of coalbed methane. The damage of coal structure can improve the gas permeability of coalbed methane.
Hewan Li, Jianping Zuo, Laigui Wang, Pengfei Li, Xiaowei Xu   +4 more
doaj   +1 more source

Quantum dynamics of a hydrogen-like atom in a time-dependent box: non-adiabatic regime

, 2018
We consider a hydrogen atom confined in time-dependent trap created by a spherical impenetrable box with time-dependent radius. For such model we study the behavior of atomic electron under the (non-adiabatic) dynamical confinement caused by the rapidly ...
Matrasulov, D., Matveev, V. I., Rakhmanov, S.   +2 more
core   +1 more source