Results 81 to 90 of about 20,142 (297)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Discrete element models of soil-geogrid interaction [PDF]
, 2019 Geogrids are the geosynthetics of choice for soil reinforcement applications. To evaluate the efficiency of geogrid reinforcement, several methods are used including field tests, laboratory tests and numerical modeling.
CJ Jones +6 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Experimental study of strain accumulation of silica sand in a cyclic triaxial test [PDF]
, 2014 The experimental and phenomenological investigation of the elasto-plastic long-term behaviour of soils under dynamic loading is important for the development of risk analysis tools and numerical accumulation models for settlement prediction.
Benoot, Jelle +2 more
core
Numerical model for CFRP confined concrete elements subject to monotonic and cyclic loadings [PDF]
, 2009 Uniaxial cyclic and monotonic compression tests were carried out on partially and fully wrapped concrete cylinders with Carbon Fibre Reinforced Polymer (CFRP) wet lay-up sheets.
Barros, Joaquim A. O. +2 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Undrained deformation characteristic of saturated soft clay under traffic loading
Shuiwen dizhi gongcheng dizhiPrevious studies on the undrained deformation behavior of saturated soft clay under traffic loading usually ignored the effect of cyclic confining pressure.
Lei SUN, Yuke WANG
doaj +1 more source
Dynamic Properties of Compacted Cohesive Soil Based On Resonant Column Studies [PDF]
, 2015 Dynamic properties of compacted cohesive soils are required in most of the civil engineering constructions. These include construction of dams, dikes, embankments, liners and levees.
Dutta, T T, Saride, Sireesh
core
Quantum dynamics of a hydrogen-like atom in a time-dependent box: non-adiabatic regime
, 2018 We consider a hydrogen atom confined in time-dependent trap created by a spherical impenetrable box with time-dependent radius. For such model we study the behavior of atomic electron under the (non-adiabatic) dynamical confinement caused by the rapidly ...
Matrasulov, D. +2 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source