Results 91 to 100 of about 1,609,424 (285)
The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]
, 1974 For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
THE TRUSS OVERLOAD ANALYSIS UNDER CORROSIVE DEGRADATION
TASK Quarterly, 2006 A contribution to analytical and numerical tools is presented that permits deterministic evaluation of structures’ behavior under multiparameter and/or cyclic mechanical, thermal and chemical loads.
WALDEMAR DUDDA
doaj
Natural Gas Industry BCyclic-loading hydraulic fracturing generates alternating stresses and complex fracture networks in hot dry rock (HDR), but the predictive accuracy of existing models is limited by insufficient consideration of rock property degradation under cyclic ...
Jia Liu +8 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Characteristics and Behavior of Geogrid-Reinforced Aggregate under Cyclic Load
, 2003 The objective of this study is to investigate the behavior of reinforced unpaved structure under cyclic load through laboratory testing, finite element and theoretical analyses.
Leng, Jianjun
core
Applied Ocean ResearchLattice-shaped diaphragm walls (LSDWs) are increasingly used as high bearing capacity foundations for the main towers and anchorage structures of cross-sea bridges in soft marine deposits, yet a dedicated p-y framework for their horizontal cyclic ...
Jiujiang Wu +3 more
doaj +1 more source