Results 101 to 110 of about 1,609,424 (285)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Threshold Shear Strain for Cyclic Degradation of Three Clays [PDF]
, 2010 Cyclic threshold shear strain, γt, is small cyclic shear strain amplitude above which soil properties significantly change with the number of cycles, N, and below which such changes are for all practical purposes negligible.
Vucetic, Mladen, Tabata, Kentaro
core +1 more source
BuildingsThe surrounding rocks of roadways are typically subjected to cyclic loading–unloading stress states in underground engineering. In addition, cyclic loads are discontinuous under real working conditions, usually while loading rock mass in a cycle ...
Ning Jiang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
Nature Communications, 2019 Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in ...
Toshiki Nagakubo +4 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
, 2000 Nonlinear analysis of batter piles in soft clay is performed using the finite element technique. As the batter piles are not only governed by lateral load but also axial load, the effect of P- Delta moment and geometric stiffness matrix is included in ...
Rajashree, SS, Sitharam, TG
core
Cyclic J-integral using the linear matching method [PDF]
, 2013 The extended version of the latest Linear Matching Method (LMM) has the capability to evaluate the stable cyclic response, which produces cyclic stresses, residual stresses and plastic strain ranges for the low cycle fatigue assessment with cyclic load ...
Chen, Haofeng, Chen, Weihang
core +2 more sources
Kenaf Fibre Reinforced Polypropylene Composites: Effect of Cyclic Immersion on Tensile Properties
International Journal of Polymer Science, 2015 This research studied the degradation of tensile properties of kenaf fibre reinforced polypropylene composites due to cyclic immersion into two different solutions, as well as comparison of the developed composites’ tensile properties under continuous ...
W. H. Haniffah +5 more
doaj +1 more source