Results 141 to 150 of about 439,193 (238)

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. [PDF]

Proc Natl Acad Sci U S A, 2020
Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR.   +5 more
europepmc   +1 more source

FOXC1: A Key Transcription Factor of VSMC‐Derived Foam Cell Formation in Atherosclerotic Plaque Instability

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life‐threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)‐derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC‐derived foam cells and IPH by analyzing data from human ...
Ling‐Lin Qian, Xue‐Ling Li, Li‐Hong Wang, Wei Yang, Yu Jiang   +4 more
wiley   +1 more source

Amine oxide lipid nanoparticles for delivery of cyclic dinucleotides. [PDF]

Natl Sci Rev
Chen Y, Yang Y, Xiao F, Wang Q, Chen S, Li J, Wang S, Zhang Y, Wu J, Jiang X.   +9 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING. [PDF]

Immunity
Ragland SA, Lindblad KE, Li Y, Choi JH, Okin D, Mao JQ, Richmond-Buccola D, Coronado DR, Brown MR, Snapper SB, Kranzusch PJ, Kagan JC.   +11 more
europepmc   +1 more source

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Chemically Regulated STING-Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity. [PDF]

Angew Chem Int Ed Engl
Xie Z, Liu H, Yang Y, Sun X, Wang J, Liu T, Wang B, Qiu W, Sun Y, Bai Y, Zhang Y, Ma D, Xiang R, Li S, Xi Z.   +14 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses. [PDF]

J Exp Med
Vila IK, Messaoud-Nacer Y, Taffoni C, Jardine J, Eloiflin RJ, Augereau A, Guha S, Schussler M, Le Hars P, McKellar J, Carvalho T, Postal J, Chemarin M, Re J, Guivel-Benhassine F, Lopez R, Trillet K, Barrat J, Serbier M, El Mansouri I, Luchsinger C, Chrousos GP, Porrot F, Diaz-Griffero F, Schwartz O, Blanchet FP, Majzoub K, Bidère N, Vlachakis D, Laguette N.   +29 more
europepmc   +1 more source

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. [PDF]

Front Immunol, 2020
Walker MM, Kim S, Crisler WJ, Nguyen K, Lenz LL, Cambier JC, Getahun A.   +6 more
europepmc   +1 more source