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Structural and biochemical insights into the inhibition of <i>Mycobacterium tuberculosis</i> cyclic dinucleotide phosphodiesterase by a sulfur-modified cyclic dinucleotide analog. [PDF]
RSC Chem BiolHanuman DS +5 more
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cGAS/STING Signaling in Ulcerative Colitis: Mechanism and Therapeutic Opportunities. [PDF]
Int J Mol SciDai X, Zhang J, Tang X.
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Profiling Nucleotide Signalling Pathways and STING Agonist Activity with a Nucleotide Library
Bekere I +4 more
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Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides [PDF]
Molecular CellCyclic-oligonucleotide-based anti-phage signaling system (CBASS) is a common immune system that uses cyclic oligonucleotide signals to limit phage replication. In turn, phages encode anti-CBASS (Acb) proteins such as Acb2, which can sequester some cyclic
Yue Feng, Xueli Cao
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Detection of Cyclic Dinucleotides by STING
2017STING (stimulator of interferon genes) is an essential signaling adaptor protein mediating cytosolic DNA-induced innate immunity for both microbial invasion and self-DNA leakage. STING is also a direct receptor for cytosolic cyclic dinucleotides (CDNs), including the microbial secondary messengers c-di-GMP (3',3'-cyclic di-GMP), 3',3'cGAMP (3',3 ...
Xiao-Xia, Du, Xiao-Dong, Su
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Enzymatic Degradation of Linear Dinucleotide Intermediates of Cyclic Dinucleotides
2020Bacterial cyclic dinucleotides (cyclic di-GMP, cyclic di-AMP, and cyclic GMP-AMP) are signaling molecules that bind to intracellular receptors to regulate a wide range of processes. In response to environmental changes, bacteria alter the rate of both synthesis and degradation to control the concentration of cyclic dinucleotides.
Mona W. Orr, Vincent T. Lee
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Cyclic Dinucleotide Signaling in Mycobacteria
2020The success of a pathogen depends on its ability for long-term survival under hostile environmental conditions. In this regard, second nucleotide messengers like cyclic di-GMP and cyclic di-AMP play a major role. In mycobacteria, cyclic di-GMP has been shown to be involved in several fundamental phenotypes like cell division, biofilm formation, and ...
Anushya Petchiappan +2 more
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