Marine Drugs, 2022 Investigation of the cytotoxic fractions of the ethyl acetate extract of the fermentation broth of the tunicate-derived Aspergillus sp. DY001 afforded two new dipeptides, asperopiperazines A and B (1 and 2), along with the previously reported compounds (+
Diaa T. A. Youssef +2 more
doaj +1 more source
Quantum mechanical calculation of the effects of stiff and rigid constraints in the conformational equilibrium of the Alanine dipeptide [PDF]
, 2006 If constraints are imposed on a macromolecule, two inequivalent classical models may be used: the stiff and the rigid one. This work studies the effects of such constraints on the Conformational Equilibrium Distribution (CED) of the model dipeptide HCO-L-
Abagyan +95 more
core +3 more sources
Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. [PDF]
, 2017 Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration.
Adler-Abramovich, Lihi +10 more
core +3 more sources
The tRNA-Dependent Biosynthesis of Modified Cyclic Dipeptides [PDF]
International Journal of Molecular Sciences, 2014 In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacterial cell wall biosynthesis and lipid modification to protein turnover and secondary metabolite assembly.
Giessen, Tobias W., Marahiel, Mohamed A.
openaire +2 more sources
Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]
, 2005 MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga +6 more
core +1 more source
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors [PDF]
, 2018 New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction.
Carrillo Fernández, Paloma +7 more
core +3 more sources
Molecules, 2014 A series of linear and macrocyclic peptides 3–12 were synthesized using 3,5-pyridinedicarboxylic acid (1) as starting material and screened for their antimicrobial, anti-inflammatory and anticancer activities.
Suzan Khayyat, Abd El-Galil Amr
doaj +1 more source
Stereoselective synthesis of α-amino-C-phosphinic acids and derivatives [PDF]
, 2016 α-Amino-C-phosphinic acids and derivatives are an important group of compounds of synthetic and medicinal interest and particular attention has been dedicated to their stereoselective synthesis in recent years. Among these, phosphinic pseudopeptides have
Cativiela, Carlos +3 more
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Protein synthesis with conformationally constrained cyclic dipeptides
Bioorganic & Medicinal Chemistry, 2020 We have synthesized several conformationally constrained dipeptide analogues as possible substrates for incorporation into proteins. These have included three cyclic dipeptides formed from Boc derivatives of 2,4-diaminobutyric acid, ornithine and lysine, having 5-, 6-, and 7-membered lactam rings, respectively.
Chao, Zhang +3 more
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Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus
Natural Products and Bioprospecting, 2023 Three previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated from the cultures of Cordyceps cicadae JXCH1, an entomopathogenic fungus.
Jing Fan +3 more
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