Enzymatical and microbial degradation of cyclic dipeptides (diketopiperazines) [PDF]
AMB Express, 2013 Diketopiperazines (DKPs) are cyclic dipeptides, representing an abundant class of biologically active natural compounds. Despite their widespread occurrence in nature, little is known about their degradation. In this study, the enzymatical and microbial cleavage of DKPs was investigated.
Perzborn, M., Syldatk, C., Rudat, J.
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Rational and combinatorial tailoring of bioactive cyclic dipeptides [PDF]
Frontiers in Microbiology, 2015 Modified cyclic dipeptides represent a diverse family of microbial secondary metabolites. They display a broad variety of biological and pharmacological activities and have long been recognized as privileged structures with the ability to bind to a wide range of receptors.
Tobias Wolfgang Giessen +2 more
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Recent research of peptide-based hydrogel in nervous regeneration
Bioactive MaterialsNeurological disorders exert significantly affect the quality of life for patients, necessitating effective strategies for nerve regeneration. Both traditional autologous nerve transplantation and emerging therapeutic approaches encounter scientific ...
Chunmei Xie +7 more
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Pharmacological Research, 2022 Ischemic/reperfusion (IR) can cause adverse reactions including apoptosis, oxidative stress, and inflammation, but the existing therapeutic strategies have been limited.
Jiale Cai +10 more
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Protein synthesis with conformationally constrained cyclic dipeptides
Bioorganic & Medicinal Chemistry, 2020 We have synthesized several conformationally constrained dipeptide analogues as possible substrates for incorporation into proteins. These have included three cyclic dipeptides formed from Boc derivatives of 2,4-diaminobutyric acid, ornithine and lysine, having 5-, 6-, and 7-membered lactam rings, respectively.
Chao, Zhang +3 more
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Effects of Cyclic High Ambient Temperature on Muscle Imidazole Dipeptide Content in Broiler Chickens
The Journal of Poultry ScienceImidazole dipeptides possess important bioregulatory properties in animals. This study aimed to evaluate the effect of high ambient temperature on muscle imidazole dipeptides (carnosine, anserine, and balenine) in broiler chickens.
Ayumi Katafuchi +8 more
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A minimalistic hydrolase based on co-assembled cyclic dipeptides [PDF]
Organic & Biomolecular Chemistry, 2019 Cyclic dipeptides based on proteinogenic amino acids form higher aggregates in water with an enzyme-like activity. Are they relevant for abiogenesis?
Alexander Kleinsmann, Boris Nachtsheim
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Free Energies of Reaction for Aqueous Glycine Condensation Chemistry at Extreme Temperatures
Geophysical Monograph Series, Page 271-283., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Matthew Kroonblawd, Nir Goldman
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Frontiers in Microbiology, 2020 A new polyketide derivative, nafuredin C (1), a novel heterocyclic dipeptide, trichodermamide G (3), together with four known biogenetically related compounds nafuredin A (2), trichodermamide A (4), aspergillazin A (5), and peniisocoumarin H (6), were ...
Dong-Lin Zhao +9 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
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