Results 21 to 30 of about 863,677 (247)

A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2019
Peptide-based supramolecular hydrogels as functional soft materials hold great promising for biomedical applications. However, much effort has been devoted to the finding and development of linear peptide hydrogelators and related hydrogel materials ...
Xuehai Yan, Chengqian Yuan, Ruirui Xing   +2 more
exaly   +2 more sources

Antimicrobial and antibiofilm effects of cyclic dipeptide-rich fraction from Lactobacillus plantarum loaded on graphene oxide nanosheets [PDF]

Frontiers in Microbiology
IntroductionOne effective method to combat bacterial infections is by using bacteria itself as a weapon. Lactobacillus is a type of fermenting bacterium that has probiotic properties and has demonstrated antimicrobial benefits against other bacteria ...
Farid Shirmardi Dezaki, Tahmineh Narimani, Mustafa Ghanadian, Elham Bidram, Farkhondeh Poursina   +4 more
doaj   +2 more sources

Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions

Frontiers in Chemistry, 2021
Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs
Yeting Guo, Yeting Guo, Jianxi Ying, Jianxi Ying, Dongru Sun, Dongru Sun, Yumeng Zhang, Minyang Zheng, Minyang Zheng, Ruiwen Ding, Ruiwen Ding, Yan Liu, Yufen Zhao, Yufen Zhao, Yufen Zhao, Yufen Zhao   +15 more
doaj   +1 more source

Genome-Guided Discovery of Natural Products through Multiplexed Low-Coverage Whole-Genome Sequencing of Soil Actinomycetes on Oxford Nanopore Flongle

mSystems, 2021
Genome mining is an important tool for discovery of new natural products; however, the number of publicly available genomes for natural product-rich microbes such as actinomycetes, relative to human pathogens with smaller genomes, is small.
Rahim Rajwani, Shannon I. Ohlemacher, Gengxiang Zhao, Hong-Bing Liu, Carole A. Bewley   +4 more
doaj   +1 more source

Novel glyproline GZK-111 with neuropsychotropic activity

Фармакокинетика и Фармакодинамика, 2022
Thе article represents a review of our own researches, which describes the design, synthesis and pharmacological properties of linear substituted glyproline GZK-111, a potential drug for the complex treatment of psychiatric pathologies, including anxiety,
K. N. Koliasnikova, A. G. Alyaeva, E. A. Kuznetsova   +2 more
doaj   +1 more source

Conformation for a beta-cyclodextrin monosubstituted with a cyclic dipeptide. [PDF]

Proceedings of the National Academy of Sciences, 1992
The structural characterization of a beta-cyclodextrin monosubstituted with the peptide cyclo(L-His-L-Leu) is reported. This work provides an x-ray example of a covalently bound group that folds in such a way that the terminal apolar side chain is retained in the hydrophobic interior of the cone-shaped cyclodextrin cavity.
Di Blasio B., PAVONE, VINCENZO, NASTRI, FLAVIA, Isernia C., Saviano M., Pedone C. ., Cucinotta V., Impellizzeri G., Rizzarelli E., Vecchio G.   +9 more
openaire   +7 more sources

The tRNA-Dependent Biosynthesis of Modified Cyclic Dipeptides [PDF]

International Journal of Molecular Sciences, 2014
In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacterial cell wall biosynthesis and lipid modification to protein turnover and secondary metabolite assembly.
Giessen, Tobias W., Marahiel, Mohamed A.
openaire   +2 more sources

Asperopiperazines A and B: Antimicrobial and Cytotoxic Dipeptides from a Tunicate-Derived Fungus Aspergillus sp. DY001

Marine Drugs, 2022
Investigation of the cytotoxic fractions of the ethyl acetate extract of the fermentation broth of the tunicate-derived Aspergillus sp. DY001 afforded two new dipeptides, asperopiperazines A and B (1 and 2), along with the previously reported compounds (+
Diaa T. A. Youssef, Lamiaa A. Shaala, Grégory Genta-Jouve   +2 more
doaj   +1 more source

Cyclic dipeptides and the human microbiome: Opportunities and challenges

Bioorganic & Medicinal Chemistry, 2023
Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis.Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs), into their ...
Ogilvie, Charlene Elizabeth, Melo Czekster, Clarissa   +1 more
openaire   +3 more sources

Synthesis and Biological Activities of Some New (Nα-Dinicotinoyl)- bis-L-Leucyl Linear and Macrocyclic Peptides

Molecules, 2014
A series of linear and macrocyclic peptides 3–12 were synthesized using 3,5-pyridinedicarboxylic acid (1) as starting material and screened for their antimicrobial, anti-inflammatory and anticancer activities.
Suzan Khayyat, Abd El-Galil Amr
doaj   +1 more source