Results 81 to 90 of about 18,412 (234)
Aqueous Amino Acids and Proteins Near the Surface of Gold in Hydrophilic and Hydrophobic Force Fields [PDF]
, 2014 We calculate potentials of the mean force for twenty amino acids in the vicinity of the (111) surface of gold, for several dipeptides, and for some analogs of the side chains, using molecular dynamics simulations and the umbrella sampling method.
Cieplak, Marek, Nawrocki, Grzegorz
core +1 more source
Molecules, 2011 This study reports the synthesis and characterization of novel ruthenium (II) complexes with the polydentate dipeptide, L-carnosine (2-[(3-aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoic acid). Mixed-ligand complexes with the general composition [MLp(
Myalo Sabela +4 more
doaj +1 more source
Synthesis of IB-01212 by multiple N-methylations of peptide bonds. [PDF]
, 2014 There are many natural peptides with multiple N-methylamino acids that exhibit potent attractive biological activities. N-methylation of a peptide bond(s) is also one of the standard approaches in medicinal chemistry of bioactive peptides, to improve the
Fujii, Nobutaka +4 more
core +1 more source
Energetics of Cyclic Dipeptide Crystal Packing and Solvation
Biophysical Journal, 1997 Calculations of the thermodynamics of transfer of the cyclic alanine-alanine (cAA) and glycine-glycine (cGG) dipeptides between the gas, water, and crystal phases were carried out using a combination of molecular mechanics, normal mode analysis, and continuum electrostatics. The experimental gas-to-water solvation free energy and the enthalpy of gas-to-
Brady, G.Patrick, Sharp, Kim A.
openaire +2 more sources
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
AMB Express, 2021 Gordonia sp. are members of the actinomycete family, their contribution to the environment improvement and environmental protection by their biological degradation ability, but there are few studies on the antimicrobial activity of their secondary ...
Yan Ma +6 more
doaj +1 more source
Homochirality in an early peptide world
, 2006 A recently proposed model of non-autocatalytic reactions in dipeptide reactions leading to spontaneous symmetry breaking and homochirality is examined. The model is governed by activation, polymerization, epimerization and depolymerization of amino acids.
Axel Brandenburg +3 more
core +2 more sources
Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. [PDF]
, 2016 The cyclo-dipeptide substrates of the essential M. tuberculosis (Mtb) enzyme CYP121 were deconstructed into their component fragments and screened against the enzyme.
Ahmad +43 more
core +2 more sources
Conformation for a beta-cyclodextrin monosubstituted with a cyclic dipeptide. [PDF]
Proceedings of the National Academy of Sciences, 1992 The structural characterization of a beta-cyclodextrin monosubstituted with the peptide cyclo(L-His-L-Leu) is reported. This work provides an x-ray example of a covalently bound group that folds in such a way that the terminal apolar side chain is retained in the hydrophobic interior of the cone-shaped cyclodextrin cavity.
Di Blasio B. +9 more
openaire +7 more sources
ChemistryEurope, EarlyView.Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn +6 more
wiley +1 more source