Results 171 to 180 of about 464,022 (216)

Linear and cyclic dipeptides with antimalarial activity

Bioorganic & Medicinal Chemistry Letters, 2012
Several natural and synthetic polypeptides possess important antimalarial activity. Shorter peptides with potent antimalarial activity have also been described, among them linear di-, tri-, tetra- and pentapeptides and their cyclic analogs. In an attempt to find dipeptides with antimalarial activities we show that linear and cyclic dipeptides, the ...
Lemuel, Pérez-Picaso, Horacio F, Olivo, Rocío, Argotte-Ramos, María, Rodríguez-Gutiérrez, María Yolanda, Rios   +4 more
openaire   +2 more sources

Reversibly Thermochromic Cyclic Dipeptide Nanotubes

Langmuir, 2018
Owing to their capability of forming extensive hydrogen bondings and the facile introduction of chirality, cyclic dipeptides (CDPs) have gained great attention as scaffolds for functional supramolecules. Surprisingly, introduction of a photopolymerizable diacetylene (DA) moiety to the CDP afforded nanotubular structures with enhanced stability and ...
Min Jeong Seo, Jisoo Song, Chandra Kantha, Mohammed Iqbal Khazi, Umesha Kundapur, Jung-Moo Heo, Jong-Man Kim   +6 more
openaire   +2 more sources

Conformational analysis of cyclic dipeptides: I. , , , and

Russian Journal of Bioorganic Chemistry, 2008
Conformational analysis of two pairs of synthetic cyclodipeptides formed by interaction of both side chain functional groups [Formula: see text] and of the main and side chains [Formula: see text] was achieved by the method of molecular mechanics. The energetically optimal conformational states of the molecules under study were determined. It was shown
S F, Arkhipova, I V, Artem'ev, E A, Goriacheva, V Z, Pletnev   +3 more
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EMPIRICAL CALCULATIONS ON CYCLIC DIPEPTIDES

International Journal of Peptide and Protein Research, 1980
Empirical conformational energy calculations were carried out for the dipeptides cyclo‐(L‐Asp‐L‐His) and cyclo‐(L‐Glu‐L‐His). The side chain conformations have been studied for various DKP ring structures, demonstrating that distortions can modify the stability of some conformations by favouring peptide backboneside chain or side chain ‐ side chain ...
M. GENEST, M. PTAK
openaire   +1 more source

Cyclic dipeptides exhibit potency for scavenging radicals

Bioorganic & Medicinal Chemistry, 2012
Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)
Tadashi, Furukawa, Takashi, Akutagawa, Hitomi, Funatani, Toshikazu, Uchida, Yoshihiro, Hotta, Masatake, Niwa, Yoshiaki, Takaya   +6 more
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The optical properties of tyrosine‐containing cyclic dipeptides

Biopolymers, 1977
AbstractThe chiroptical properties of the cyclic dipeptides cyclo (L‐alanyl‐L‐tyrosine) and cyclo(L‐tyrosyl‐L‐tyrosine) have been investigated as a function of molecular conformation. Theoretical optical calculations and conformational energy calculations have been carried out as a function of the side‐chain dihedral angles χ1 and χ2, and as a function
J W, Snow, T M, Hooker, J A, Schellman
openaire   +2 more sources

Synthesis of New Functionalized Cyclic Dipeptide

Synthetic Communications, 1997
Abstract An efficient method has been developed for the synthesis of the functionalized cyclic dipeptide 6. The key step involves cyclisation of the linear dipeptide prepared by coupling a suitably protected β-amino acid with N-benzyl-t-butylglycinate.
O. El Mahdi, J. P. Lavergne, J. Martinez, Ph. Viallefont, C. Riche   +4 more
openaire   +1 more source

EMPIRICAL CALCULATIONS ON CYCLIC DIPEPTIDES

International Journal of Peptide and Protein Research, 1978
Empirical conformational energy calculations were carried out for the dipeptides cyclo‐(L‐Ser‐L‐His) and cyclo‐(L‐Thr‐L‐His). Various DKP structures have been investigated to study side chain conformations through the DKP ring deformations, and prevalent conformers of monosubstituted and disubstituted dipeptides are discussed.
M, Genest, M, Ptak
openaire   +2 more sources

Quantum chemical study of cyclic dipeptides

International Journal of Quantum Chemistry, 2006
AbstractThe preferred conformations of cyclic dipeptides were first studied systemically using the density functional theory (DFT) B3LYP method at the 6‐31G(d) level. The structural characteristics of cyclic dipeptides were revealed, most of which have not been confirmed until now.
Yanyan Zhu, Mingsheng Tang, Xiaoyu Shi, Yufen Zhao   +3 more
openaire   +1 more source

Two-Dimensional Coordination Networks from Cyclic Dipeptides

Journal of the American Chemical Society, 2020
Peptide-based biomimetic nanostructures and metal-organic coordination networks on surfaces are two promising classes of hybrid materials which have been explored recently. However, despite the great versatility and structural variability of natural and synthetic peptides, the two directions have so far not been merged in fabrication of metal-organic ...
Yuanyuan Guo, Ajiguli Nuermaimaiti, Niels Due Kjeldsen, Kurt V. Gothelf, Trolle R. Linderoth   +4 more
openaire   +2 more sources