Results 211 to 220 of about 10,177 (227)
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Theoretical UV Circular Dichroism of Aliphatic Cyclic Dipeptides
The Journal of Physical Chemistry A, 2005Four cyclic dipeptides (piperazine-2,5-diones), cyclo(L-Pro-Gly), cyclo(L-Pro-L-Leu), cyclo(L-Ala-L-Ala), and cyclo(L-Pro-L-Ala), were modeled from crystal structure data. Conformations resulting from energy minimization using molecular mechanics were compared with traditional ab initio and density functional theory geometric optimizations for each ...
Kristine L, Carlson +3 more
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EMPIRICAL CALCULATIONS ON CYCLIC DIPEPTIDES
International Journal of Peptide and Protein Research, 1978Empirical conformational energy calculations were carried out for the dipeptides cyclo‐(L‐Ser‐L‐His) and cyclo‐(L‐Thr‐L‐His). Various DKP structures have been investigated to study side chain conformations through the DKP ring deformations, and prevalent conformers of monosubstituted and disubstituted dipeptides are discussed.
M, Genest, M, Ptak
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ChemInform Abstract: CONFORMATIONAL STUDIES ON CYCLIC DIPEPTIDES
Chemischer Informationsdienst, 1977AbstractDie Kristallstrukturen von 1 1 cycli‐ schen Dipeptiden der allgemeinen Formel (I) werden analysiert und die bevorzugten Konformationen der Seitenketten und des Ringes mit Hilfe der klassischen Energiekalkulationen untersucht.
R. RAMANI +2 more
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Synthesis of mono Nα-trifluoroethylated cyclic dipeptides
Tetrahedron Letters, 2006Abstract Trifluoroethylated N-termini in linear dipeptides l -TyrXOR [X = Gly, d -Ala, l -Leu, l -Phe, and l -Glu; R = H, Me, Et] exhibit sufficient nucleophilicity to give piperazine-2,5-dione ring formation through intramolecular cyclization reaction in acidic aqueous solutions. The reactions occur in high yield and with absolute configuration
Darryl D. DesMarteau, Changqing Lu
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Synthesis and evaluation of eight-membered cyclic pseudo-dipeptides
Peptides, 2005In the course of the development of calpain inhibitors, we report the synthesis of eight-membered cyclic pseudo dipeptides closely related to the known inhibitor SJA6017. The ring closure was effected by metathesis of the diallyl-substituted dipeptides 6 and 7. The formation of the dipeptides under kinetic control leads to the preferential formation of
Abell, A. +7 more
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Breaking Cyclic Dipeptide Prenyltransferase Regioselectivity by Unnatural Alkyl Donors
Organic Letters, 2013The behavior of five cyclic dipeptide prenyltransferases, responsible for C2-regular, C2-reverse, or C3-reverse prenylation, was investigated in the presence of the unnatural alkyl donors monomethylallyl and 2-pentenyl diphosphate. Both substrates were well accepted by the tested enzymes.
Mike, Liebhold +2 more
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Dietary cyclic dipeptides, apoptosis and psychiatric disorders: A hypothesis
Medical Hypotheses, 2014Cyclic dipeptides from food and intestinal yeast cyclic dipeptides may play a role in causing psychiatric disorders such as schizophrenia. From cancer research, cyclic dipeptides such as cyclo (proline-phenylalanine) have been found to activate the pathways of apoptosis and to cause programmed cell death.
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Cyclic Dipeptides from Streptomyces michiganensis
Chemistry of Natural Compounds, 2015Jinghua Xue, Min Wu
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