Results 181 to 190 of about 9,771 (260)

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Coupling conversion of CO/CO₂ to chemicals through zeolite catalysis. [PDF]

Chem Sci
Wei C, Gao S, Qi L, Liu Z.
europepmc   +1 more source

Calcium‐Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids

Advanced Science, EarlyView.
Mechanochemically generated organocalcium species display unusual chemoselectivity toward carboxylates, enabling direct ketone synthesis without overaddition. Ball milling activates commercial calcium metal under ambient, solvent‐minimized conditions, providing a broad substrate scope, high functional‐group tolerance, and a practical one‐step ...
Mengyao Pei, Zekun Yang, Xueyan Yang, Yufang Yang, Yangyang Shen, Jiemin Wang, Peile Ma, Zezhu Li, Xiaoliang Zheng, Xiaofeng Wei   +9 more
wiley   +1 more source

Computational study of the effect of Lewis base additives and molecular spin state in SmI₂-chemistry. [PDF]

Chem Sci
Yu S, Romano C, Procter DJ, Kaltsoyannis N.   +3 more
europepmc   +1 more source

Mechanochemical Piezoelectric Catalysis: Advancing the Hydrogenation of Alkenes

Advanced Science, EarlyView.
This study presents mechanochemical piezoelectric catalysis for alkene hydrogenation, eliminating the need for transition metals, H2, and solvents. The method effectively hydrogenates diverse activated and unactivated alkenes and shows potential for modifying bioactive molecules in pharmaceuticals.
Zixi Ai, Mengting Liu, Xiaohong Wang, Xiaochun He, Xuemei Zhang, Zhong Lian   +5 more
wiley   +1 more source

Borate-Bridged Protolipids: A Prebiotic Route to Abiotic Membranes. [PDF]

Life (Basel)
Dembitsky VM, Terent'ev AO, Scorei IRI.
europepmc   +1 more source

Interface‐Directed High Fluorescence Efficiency Two‐Dimensional Molecular Crystals With Surface‐Exposed Active Sites

Advanced Science, EarlyView.
Here, we designed the Me‐FBSe molecule and prepared a two‐dimensional molecular crystal via liquid‐liquid interface assembly. The crystal preserves the high photoluminescence quantum while simultaneously ensuring the high‐density surface exposure of active sites.
Shuya Liu, Yueqiang Zhang, Chuanqin Cheng, Jin Wang, Feiyong Chen, Yonglei Wang, Yanjun Gong   +6 more
wiley   +1 more source

Catalytic asymmetric construction of remote P or other heteroatom (Si/S) stereogenic axially chiral scaffolds. [PDF]

Chem Sci
Liu W, Ling Z, Liu YZ, Deng WP.
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source