Results 1 to 10 of about 760,941 (399)
Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence. [PDF]
PLoS Pathogens, 2014 Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Shi-qi An +7 more
doaj +5 more sources
The effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway on organ inflammatory injury and fibrosis [PDF]
Frontiers in Pharmacology, 2022 The cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction pathway is critical in innate immunity, infection, and inflammation.
Yuliang Liu +26 more
doaj +2 more sources
Cyclic GMP and PKG Signaling in Heart Failure [PDF]
Frontiers in Pharmacology, 2022 Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by two intrinsic pathways: nitric oxide (NO)-soluble GC and natriuretic peptide (NP)
Genri Numata +3 more
doaj +2 more sources
ROS-GC interlocked Ca2+-sensor S100B protein signaling in cone photoreceptors: Review [PDF]
Frontiers in Molecular Neuroscience, 2014 Photoreceptor rod outer segment membrane guanylate cyclase (ROS-GC) is central to visual transduction; it generates cyclic GMP, the second messenger of the photon signal.
Rameshwar K Sharma +3 more
doaj +4 more sources
Cyclic di-GMP: second messenger extraordinaire [PDF]
Nature Reviews Microbiology, 2017 Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP).
Jenal, Urs +2 more
core +2 more sources
Journal of Innate Immunity, 2021 Within the last 60 years, microbiological research has challenged many dogmas such as bacteria being unicellular microorganisms directed by nutrient sources; these investigations produced new dogmas such as cyclic diguanylate monophosphate (cyclic di-GMP)
Agaristi Lamprokostopoulou, Ute Römling
doaj +1 more source
Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone
Nature Communications, 2022 Cyclic-di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Here, the authors show that AI-2 and bile salts induce cyclic-di-GMP synthesis via YeaJ and YedQ, respectively, to repress the T3SS ...
Shuyu Li +13 more
doaj +1 more source
Crystal structure and functional implication of bacterial STING
Nature Communications, 2022 The bacterial Cyclic-oligonucleotide-Based Anti-phage Signaling System (CBASS) contains a CD-NTase that synthesizes cyclic di- and tri-nucleotides, and bacterial STING proteins recognize c-di-GMP generated by CD-NTase during phage infection and signal ...
Tzu-Ping Ko +6 more
doaj +1 more source
Microbiology Spectrum, 2023 Dickeya dadantii is a Gram-negative bacterium that causes soft rot diseases in a variety of plants. This pathogen secretes pectate lyase (Pel) enzymes to degrade the plant cell wall, a process controlled by the bacterial second messenger cyclic ...
Biswarup Banerjee +2 more
doaj +1 more source
Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides. [PDF]
PLoS ONE, 2013 The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines.
Guanghui Yi +5 more
doaj +1 more source