An auto-inhibited state of protein kinase G and implications for selective activation
eLife, 2022 Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates biological functions as diverse as smooth muscle contraction, cardiac function, and axon guidance ...
Rajesh Sharma +12 more
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Cyclic AMP‐dependent protein kinase does not phosphorylate cyclic GMP‐dependent protein kinase in vitro [PDF]
FEBS Letters, 1983 The autophosphorylation reaction of purified cGMP‐dependent protein kinase has been studied. Apparent initial rates of autophosphorylation in the absence of cyclic nucleotides and in the presence of cGMP and cAMP are 0.006, 0.04, 0.4 mol. Pi incorp./min−1.mol cGMP‐kinase subunit−1.
Hofmann, F., Gensheimer, H.-P.
openaire +4 more sources
Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. [PDF]
PLoS ONE, 2011 Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for regulating smooth muscle tone, platelet activation, nociception and memory formation.
Jeong Joo Kim +10 more
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Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation
Frontiers in Pharmacology, 2020 Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic ...
Junzhong Lai +17 more
doaj +1 more source
ncRNAs and polyphenols: new therapeutic strategies for hypertension
RNA Biology, 2022 Polyphenols have gained significant attention in protecting several chronic diseases, such as cardiovascular diseases (CVDs). Accumulating evidence indicates that polyphenols have potential protective roles for various CVDs.
Elham Shirazi-Tehrani +3 more
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Cell Reports, 2020 Summary: Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease.
Katherine R. Balka +15 more
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Cyclic Nucleotide-Directed Protein Kinases in Cardiovascular Inflammation and Growth
Journal of Cardiovascular Development and Disease, 2018 Cardiovascular disease (CVD), including myocardial infarction (MI) and peripheral or coronary artery disease (PAD, CAD), remains the number one killer of individuals in the United States and worldwide, accounting for nearly 18 million (>30%) global ...
Nathan A. Holland +6 more
doaj +1 more source
PPP6C Negatively Regulates STING-Dependent Innate Immune Responses
mBio, 2020 Stimulator of interferon genes (STING) is an essential adaptor protein of the innate DNA-sensing signaling pathway, which recognizes genomic DNA from invading pathogens to establish antiviral responses in host cells.
Guoxin Ni +6 more
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The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant [PDF]
, 2013 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials.
Akira, S +11 more
core +5 more sources
Downstream Targets of Cyclic Nucleotides in Plants
Frontiers in Plant Science, 2018 Efficient integration of various external and internal signals is required to maintain adaptive cellular function. Numerous distinct signal transduction systems have evolved to allow cells to receive these inputs, to translate their codes and ...
Brygida Świeżawska +3 more
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