Results 131 to 140 of about 19,300 (178)
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Localization of cyclic GMP-dependent protein kinase in human mononuclear phagocytes
Journal of Leukocyte Biology, 1995Abstract The presence and physiological role of cGMP-dependent protein kinase (G-kinase) was investigated in human mononuclear phagocytes. Western blots of mono cyte extracts revealed a single polypeptide band that comigrated with purified bovine lung G-kinase.
K B, Pryzwansky +4 more
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Cyclic GMP-Dependent Protein Kinase Regulates Vascular Smooth Muscle Cell Phenotype
Journal of Vascular Research, 1997Nitric oxide (NO) and cyclic guanosine 3',5'-monophosphate (cGMP) have been reported to prevent vascular smooth muscle cell (VSMC) proliferation and have beneficial effects to reduce intimal thickening in response to arterial injury. The purpose of this study was to determine whether the downstream effector molecule of NO-cGMP signaling, cyclic GMP ...
N J, Boerth +3 more
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Cyclic GMP-dependent protein kinase-I in the guinea pig cochlea
Hearing Research, 1999Recent studies have begun to characterize the nitric oxide/cyclic GMP/protein kinase G pathway in the mammalian cochlea by demonstrating the presence of both the enzyme that produces nitric oxide (NO), nitric oxide synthase, and the NO receptor, soluble guanylate cyclase.
F, Tian, J D, Fessenden, J, Schacht
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Ca2+-Independent stimulation of cyclic GMP-dependent protein kinase by calmodulin
Biochemical and Biophysical Research Communications, 1980Abstract Calmodulin purified from bovine brain markedly stimulated cyclic GMP-dependent protein kinase from pig lung in the presence of cyclic GMP. This stimulation by calmodulin did not require Ca2+ and was dose-dependent up to optimal amounts, but the extent of stimulation decreased at concentrations over the optimal condition.
T, Yamaki, H, Hidaka
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Increase in nuclear cyclic GMP-dependent protein kinase following partial hepatectomy
Life Sciences, 1981Abstract The level of cyclic GMP-dependent protein kinase in the nucleus of rat liver was shown to increase 80% at 3 hr following partial hepatectomy while cyclic AMP-binding activity decreased 28%. Subnuclear fractionation demonstrated that the increase in cyclic GMP-dependent protein kinase was localized to the nucleolus and nucleoplasm, with no ...
J, Tse, C W, Mackenzie, T E, Donnelly
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Cyclic GMP-Dependent Protein Kinase Activity in Rat Pulmonary Microvascular Endothelial Cells
Biochemical and Biophysical Research Communications, 1994Cyclic GMP-dependent protein kinase (cGPK) activity was determined in rat pulmonary microvascular endothelial cells (RPMVEC) using cGMP-stimulated phosphorylation of BPDEtide and histone F2B substrates in the presence of PKI [peptide inhibitor of cAMP-dependent protein kinase (cAPK)].
A H, Diwan +3 more
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Photoaffinity Labeling of Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases
1982Photoaffinity labeling is a useful technique for the study of ligand-receptor interactions. Irradiation of chemically modified ligands with light produces highly reactive intermediates which are capable of forming covalent bonds with the receptors. Photoaffinity labeling has been used for many different ligands and has been especially successful for ...
U. Walter, P. Greengard
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[47] Purification and characterization of cyclic GMP-dependent protein kinases
1974Publisher Summary Many arthropod tissues are rich in cGMP-dependent protein kinases and provide favorable material for study of the properties and function of enzymes. In contrast, it has not yet been possible to detect cGMP-dependent protein kinase activity in most vertebrate tissues examined.
J.F. Kuo, Paul Greengard
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Metabolism, 1975
Protein kinase modulator can either augment or depress phosphorylation of substrate proteins catalyzed by cyclic GMP-dependent and cyclic AMP-dependent protein kinases prepared from mammalian and arthropod tissues. Alteration by the modulator of the phosphorylating activity of the protein kinases is considered to be due to modification of protein ...
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Protein kinase modulator can either augment or depress phosphorylation of substrate proteins catalyzed by cyclic GMP-dependent and cyclic AMP-dependent protein kinases prepared from mammalian and arthropod tissues. Alteration by the modulator of the phosphorylating activity of the protein kinases is considered to be due to modification of protein ...
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