Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System [PDF]
Circulation Research, 2003 Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an important role in the maintenance of cardiovascular homeostasis. It is currently accepted that many effects of these endogenous signaling molecules are mediated via stimulation of guanylyl cyclases and intracellular production of the second messenger cGMP.
Feil, R +4 more
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Experimental approaches to understanding the role of protein phosphorylation in the regulation of neuronal function [PDF]
, 1983 Studies by Earl Sutherland and his colleagues on hormonal regulation of the breakdown of glycogen in liver resulted in the discovery that the first step in the action of many hormones is to increase the synthesis of cAMP by activating adenylate cyclase ...
Kennedy, Mary B.
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
, +11 more
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Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation [PDF]
, 1997 Most working proteins, including metabolic enzymes, transcription regulators, and membrane receptors, transporters, and ion channels, share the property of allosteric coupling. The term 'allosteric' means that these proteins mediate indirect interactions
Lester, Henry A. +2 more
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Cyclic di-GMP: second messenger extraordinaire [PDF]
, 2017 Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP).
Jenal, Urs +2 more
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Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
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Selective inhibition of intestinal guanosine 3,5-cyclic monophosphate signaling by small-molecule protein kinase inhibitors [PDF]
, 2018 The guanosine 3,5-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) serine/threonine kinase relays signaling through guanylyl cyclase C (GCC) to control intestinal fluid homeostasis.
Bijvelds, M.J.C. (Marcel) +10 more
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Cyclic nucleotide signalling in malaria parasites. [PDF]
, 2017 The cyclic nucleotides 3', 5'-cyclic adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types.
Baker, David A +6 more
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Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase. [PDF]
Journal of Biological Chemistry, 1983 In intact rat adipocytes hormone‐sensitive lipase has been shown to be phosphorylated on serine residues in two different phosphorylation sites: a regulatory site phosphorylated by cyclic AMP‐dependent protein kinase and a basal site, which does not directly affect the enzyme activity, phosphorylated by cyclic AMP‐independent protein kinase(s) [(1984 ...
Strålfors, Peter, Belfrage, Per
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Cyclic GMP in the pig vitreous and retina after experimental retinal detachment [PDF]
, 2008 Purpose: Earlier studies have revealed a decreased level of cGMP in vitreous fluid obtained from patients with a retinal detachment. To further investigate this phenomenon, we developed an experimental retinal detachment model in pigs.
Diederen, R. +5 more
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