Results 101 to 110 of about 72,449 (334)

Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases

Advanced Science, EarlyView.
Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang, Sen Yang, Xiaomi Wang, Yuanwei Zhang, Yao Zhao, Menghuan Tao, Jinyi Zhu, Wanxin Zhang, Yansu Wang, Kaixuan Duan, Yan Wang, Wenwu Ye, Zhenfei Guo, Yuanchao Wang   +13 more
wiley   +1 more source

Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model

Indian Pacing and Electrophysiology Journal, 2008
Introduction We examined the acute effects of neutral endopeptidase inhibitor on the hemodynamics and electrical properties of dogs subjected to rapid atrial pacing.
Ryuta Imaki, Shinichi Niwano, Hiroe Niwano, Daisuke Satoh, Toru Yoshida, Yoshihiko Masaki, Tohru Izumi   +6 more
doaj  

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +2 more sources

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches

Advanced Science, EarlyView.
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
wiley   +1 more source

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

Journal of Inflammation, 2009
Background Nitric oxide (NO) can be both pro- and anti-apoptotic in various cell types, including macrophages. This apparent paradox may result from the actions of NO-related species generated in the microenvironment of the cell, for example the ...
Rossi Adriano G, Webb David J, Shaw Catherine A, Megson Ian L   +3 more
doaj   +1 more source

Cyclic GMP-AMP Synthase in Cancer Prevention. [PDF]

J Cancer Prev, 2023
Chen W, Lee GE, Jeung D, Byun J, Juan W, Cho YY.   +5 more
europepmc   +1 more source

Cyclic GMP binding activity in Dictyostelium discoideum [PDF]

, 1978
José M. Mato, Henry Woelders, Peter J.M. Van Haastert, Théo M. Konijn   +3 more
openalex   +1 more source

Nanosensitizer for Cancer Radioimmunotherapy via Anti‐IL‐35 Blockade Boosted Innate Immunity Activation

Advanced Science, EarlyView.
Zheng et al. designed a tumor microenvironment (TME)‐responsive nanosystem, HmBMH@MSA‐2. It targets tumors, releases MSA‐2 and Mn ions in high glutathione (GSH) conditions, achieving STING agonist delivery and MRI. The nanosystem promotes chemodynamic therapy (CDT), achieves radiosensitization, and activates the cGAS‐STING pathway.
Yinfei Zheng, Shuting Zheng, Yushu Liao, Zede Wu, Chenxi He, Qiuyu Li, Honglei Hu, Zheyu Shen, Yikai Xu, Chenggong Yan, Bingxia Zhao, Meirong Hou   +11 more
wiley   +1 more source

Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria

Nature Communications
Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the ...
Xiaocui Ling, Xiao Liu, Kun Wang, Minhao Guo, Yanzhe Ou, Danting Li, Yulin Xiang, Jiachen Zheng, Lihua Hu, Hongyun Zhang, Weihui Li   +10 more
doaj   +1 more source

Cellular signaling with nitric oxide and cyclic GMP

Brazilian Journal of Medical and Biological Research, 1999
During the past two decades, nitric oxide signaling has been one of the most rapidly growing areas in biology. This simple free radical gas can regulate an ever growing list of biological processes.
F. Murad
doaj   +1 more source