Results 11 to 20 of about 761,984 (237)

Cyclic GMP-AMP Synthase

Definitions, 2020
Cyclic GMP-AMP synthase (522 aa, ~59 kDa) is encoded by the human CGAS gene. This protein plays a role both cyclic dinucleotide synthesis and immune response activation.

semanticscholar   +1 more source

RsmA regulates biofilm formation in Xanthomonas campestris through a regulatory network involving cyclic di-GMP and the Clp transcription factor. [PDF]

PLoS ONE, 2012
Biofilm formation and dispersal in the black rot pathogen Xanthomonas campestris pathovar campestris (Xcc) is influenced by a number of factors. The extracellular mannanase ManA has been implicated in biofilm dispersal whereas biofilm formation requires ...
Xiu-Hong Lu, Shi-Qi An, Dong-Jie Tang, Yvonne McCarthy, Ji-Liang Tang, John Maxwell Dow, Robert P Ryan   +6 more
doaj   +1 more source

Identification of a cyclic-di-GMP-modulating response regulator that impacts biofilm formation in a model sulfate reducing bacterium

Frontiers in Microbiology, 2014
We surveyed the eight putative cyclic-di-GMP-modulating response regulators (RRs) in Desulfovibrio vulgaris Hildenborough that are predicted to function via two-component signaling.
Lara eRajeev, Eric G Luning, Sara eAltenburg, Grant Matthew Zane, Edward E Baidoo, Michela eCatena, Jay D Keasling, Jay D Keasling, Judy D Wall, Matthew W Fields, Aindrila eMukhopadhyay   +10 more
doaj   +1 more source

Quantitative determination of cyclic guanosine monoposphate (c-GMP) in rat tissues using liquid chromatography and tandem mass spectrometry

Фармакокинетика и Фармакодинамика, 2023
Relevance. Cyclic 3′,5′-guanosine monophosphate is a secondary intracellular messenger that plays a key role in many physiological processes.Quantitative determination of the level of c-GMP in the tissues of laboratory animals is an urgent task of ...
N. S. Popov, V. Yu. Balabanyan, N. Yu. Kolgina, G. A. Petrov, S. A. Donskov, I. B. Atadzhanov   +5 more
doaj   +1 more source

Cyclic GMP and Cilia Motility

Cells, 2015
Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense.
Todd A. Wyatt
doaj   +1 more source

Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide

Pathogens, 2020
Human gingival fibroblasts (HGFs) recognize microbe-associated molecular patterns (MAMPs) and respond with inflammatory proteins. Simultaneous impacts of bacterial cyclic di-guanosine monophosphate (c-di-GMP), cyclic di-adenosine monophosphate (c-di-AMP),
Samira Elmanfi, Herman O. Sintim, Jie Zhou, Mervi Gürsoy, Eija Könönen, Ulvi K. Gürsoy   +5 more
doaj   +1 more source

Heterogeneity in Surface Sensing Suggests a Division of Labor in Pseudomonas aeruginosa Populations [PDF]

, 2019
The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species.
Armbuster, Catherine R., de Anda, Jaime, Harwood, Caroline S., Hoffman, Lucas R., Jin, Fan, Lee, Calvin K., Murakami, Keiji, Parker-Gilham, Jessica, Parsek, Matthew R., Tseng, Boo Shan, Wong, Gerard CL, Xia, Aiguo, Zhao, Kun   +12 more
core   +2 more sources

Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP

eLife, 2014
Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm formation, a prevalent adaptation strategy in response to changing environments.
Debashree Chatterjee, Richard B Cooley, Chelsea D Boyd, Ryan A Mehl, George A O'Toole, Holger Sondermann   +5 more
doaj   +1 more source

Progress in understanding of the molecular basis underlying functional diversification of cyclic di-nucleotide turnover proteins [PDF]

, 2016
Cyclic di-GMP was the first cyclic di-nucleotide second messenger described, presaging the discovery of additional cyclic di-nucleotide messengers in bacteria and eukaryotes.
Dow, J. Maxwell, Liang, Zhao-Xun, Römling, Ute   +2 more
core   +1 more source

Integrative signaling networks of membrane guanylate cyclases: Biochemistry and physiology

Frontiers in Molecular Neuroscience, 2016
This monograph presents a historical perspective of cornerstone developments on the biochemistry and physiology of mammalian membrane guanylate cyclases (MGCs), highlighting contributions made by the authors and their collaborators.
Rameshwar K Sharma, Teresa Duda, Clint L Makino   +2 more
doaj   +1 more source