Results 11 to 20 of about 36,202 (265)
Specificity of the cyclic GMP-bbmding activity and of a cyclic GMP-dependent cyclic GMP phosphodiesterase in Dictyostelium discoideum [PDF]
Molecular and Cellular Endocrinology, 1982 The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N2H2, N1-H and/or C6 = O, N7, 2(1)-OH and 3(1)-O and ...
Haastert, Peter J.M. van +4 more
openaire +3 more sources
Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence.
PLoS Pathogens, 2014 Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Shi-qi An +7 more
doaj +1 more source
eLife, 2014 Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm formation, a prevalent adaptation strategy in response to changing environments.
Debashree Chatterjee +5 more
doaj +1 more source
Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
Pathogens, 2020 Human gingival fibroblasts (HGFs) recognize microbe-associated molecular patterns (MAMPs) and respond with inflammatory proteins. Simultaneous impacts of bacterial cyclic di-guanosine monophosphate (c-di-GMP), cyclic di-adenosine monophosphate (c-di-AMP),
Samira Elmanfi +5 more
doaj +1 more source
Integrative signaling networks of membrane guanylate cyclases: Biochemistry and physiology
Frontiers in Molecular Neuroscience, 2016 This monograph presents a historical perspective of cornerstone developments on the biochemistry and physiology of mammalian membrane guanylate cyclases (MGCs), highlighting contributions made by the authors and their collaborators.
Rameshwar K Sharma +2 more
doaj +1 more source
PLoS ONE, 2013 The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines.
Guanghui Yi +5 more
doaj +1 more source
Guanylin peptides: cyclic GMP signaling mechanisms
Brazilian Journal of Medical and Biological Research, 1999 Guanylate cyclases (GC) serve in two different signaling pathways involving cytosolic and membrane enzymes. Membrane GCs are receptors for guanylin and atriopeptin peptides, two families of cGMP-regulating peptides.
L.R. Forte +3 more
doaj +1 more source
Nucleotides as Bacterial Second Messengers
Molecules, 2023 In addition to comprising monomers of nucleic acids, nucleotides have signaling functions and act as second messengers in both prokaryotic and eukaryotic cells. The most common example is cyclic AMP (cAMP).
Mario E. Cancino-Diaz +3 more
doaj +1 more source
Bacterial cyclic diguanylate signaling networks sense temperature
Nature Communications, 2021 Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, the authors identify a thermosensitive enzyme that synthesizes c-di-GMP and modulates temperature-dependent motility ...
Henrik Almblad +29 more
doaj +1 more source
Cyclic GMP System in Epidermis: II. Histamine Stimulates Cyclic GMP Formation
Journal of Investigative Dermatology, 1979 In search of hormones and drugs which might elevate the intracellular level of cyclic GMP in pig epidermis, we have tested the effects of carbachol, concanavalin A, prostaglandin F2α, insulin, epinephrine, Vitamin A acid and histamine. Only histamine was found to cause consistent activation of the cyclic GMP system. Epidermal slices incubated in Hank's
Iizuka, Hajime +4 more
openaire +2 more sources