Results 251 to 260 of about 611,110 (302)

Cyclic GMP-Hydrolyzing Phosphodiesterases

2009
The cyclic nucleotides (cN), cAMP and cGMP, are key second messengers that mediate the intracellular effects of many signals known as “first messengers”, including environmental signals such as photons for vision and chemicals for taste, as well as hormones, paracrine factors, neurotransmitters, or autocrine factors.
Sharron H, Francis, Jackie D, Corbin, Erwin, Bischoff   +2 more
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Cyclic AMP and Cyclic GMP

Annual Review of Pharmacology, 1974
A chapter on "Cyclic AMP and Drug Action" has already been published in Annual Review of Pharmacology (1). In spite of its restrictive title, this paper covered most of the knowledge about the biochemical and biological effects of cAMP that was available in 1969.
openaire   +1 more source

Clinical Relationships of Cyclic GMP

1994
Publisher Summary The purpose of this chapter is to review current knowledge on the clinical use of cyclic guanosine monophosphate (cGMP) measurements as markers of endogenous and exogenous ANP effects. cGMP production through the stimulation of particulate guanylate cyclase is induced by the action of atrial natriuretic peptide (ANP) on target cells.
J R, Cusson, J, Tremblay, P, Larochelle, E L, Schiffrin, J, Gutkowska, P, Hamet   +5 more
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The role of cyclic AMP and cyclic GMP in byssinosis

American Industrial Hygiene Association Journal, 1979
The lungs of female guinea pigs, either untreated or previously sensitized with aqueous extracts of cotton dust (AECD) were perfused via the pulmonary artery with 0, 10-6, 10-5 or 10-4 g/mL of lyophilized AECD in Tyrodes solution. Pressure changes in the pulmonary artery were monitored during this period.
M H, Elissalde, G A, Greenblatt
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Cyclic GMP and mechanisms of vasodilation

Pharmacology & Therapeutics, 1989
This review is the result of a widening interest in the role of cGMP in vascular smooth muscle function. Smooth muscle physiologists, pharmacologists, and biochemists now appreciate the fact that cGMP plays a key role in regulating vascular, and probably non-vascular, smooth muscle contractile ...
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The measurement of cyclic GMP and cyclic AMP phosphodiesterases

Analytical Biochemistry, 1979
Abstract Methods are described for measuring phosphodiesterases for cGMP and cAMP in the range of activity yielding 10 −12 to 10 −8 mol of product. The 5′-GMP formed is measured by conversion to GDP with guanylate kinase. Amounts of GDP greater than 10 −10 mol are measured directly with an enzyme system which results in stoichiometric oxidation of
J G, Carter, S J, Berger, O H, Lowry
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Cyclic GMP System in the Epidermis

2015
A great deal of knowledge has been gained concerning the activation of adenylate and guanylate cyclase in epidermal cells. Adenylate cyclase is activated by 4 different independent receptors-responding respectively to catecholamine (beta), to prostaglandins (E), to histamine (H2), and to adenosine and it phosphorylated derivatives.
K, Adachi, T, Aoyagi, H, Iizuka, K M, Halprin, V, Levin   +4 more
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Interaction of caspase‐3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

European Journal of Biochemistry, 2003
Here, we show that recombinant bovine PDE5A1 is proteolysed by recombinant caspase‐3 in in vitro and transfected Cos‐7 cells. In addition, the treatment of PDE5A1‐transfected Cos‐7 and PC12 cells with staurosporine, an apoptotic agent that activates endogenous caspase‐3, also induced proteolysis and inactivation of PDE5A1.
Frame, Mhairi J, Tate, Rothwelle, Adams, David R, Morgan, Keith M, Houslay, M D, Vandenabeele, Peter, Pyne, Nigel J   +6 more
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Cyclic GMP Cascade of Vision

Annual Review of Neuroscience, 1986
Cyclic GMP is central to visual excitation in vertebrate retinal rod cells. Sodium channels in the plasma membrane of the outer segment are kept open in the dark by a high level of cGMP. Light closes these channels by activating an enzymatic cascade that leads to the rapid hydrolysis of cGMP. Photoexcited rhodopsin triggers transducin by catalyzing the
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Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis

1994
Several of the different PDE isozyme families have the ability in vitro to hydrolyze cGMP. In particular they include the CaM-dependent PDEs, the cGMP-stimulated PDEs, and the cGMP binding, cGMP-specific PDEs. Existing evidence suggests or demonstrates that in different cell types, each of these can be important determinants for the control of cGMP ...
W K, Sonnenburg, J A, Beavo
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