Results 261 to 270 of about 72,449 (334)
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. [PDF]
J Biol Chem, 2020 Abdisalaam S +9 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease. [PDF]
Proc Natl Acad Sci U S A, 2020 Sharma M +4 more
europepmc +1 more source
Regulation of Cyclic GMP Synthesis and the Interactions with Calcium
, 1986 Ferid Murad +3 more
openalex +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Plasma level of norepinephrine, cyclic AMP and cyclic GMP in essential hypertension.
, 1981 Kouichi Ogawa +4 more
openalex +2 more sources
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Role of cyclic GMP of canine vascular smooth muscle in relaxation by organic nitrates.
, 1986 Tetsuo Shibata +5 more
openalex +2 more sources
Cancer Science, EarlyView.Japanese tumor genomes with whole‐genome duplication are diversified by allele imbalance and chromothripsis. These structural abnormalities are linked to a poor prognosis for cancer patients. ABSTRACT Whole‐genome analyses have revealed that large‐scale structural variations (SVs) such as whole‐genome duplication (WGD) occur early in the development of
Keiichi Hatakeyama +11 more
wiley +1 more source