Results 261 to 270 of about 40,137 (294)
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Cyclic GMP and photoreceptor function
The FASEB Journal, 1990A single photon can be detected by a rod photoreceptor cell. The absorption of light by rhodopsin triggers a cascade of reactions that amplifies the photon signal and results in ion channel closure with hyperpolarization of the rod photoreceptor cell.
R N, Lolley, R H, Lee
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Cyclic GMP Reduces Myocardial Stunning Through Non-Cyclic GMP Protein Kinase Mechanisms
Journal of Cardiovascular Pharmacology, 2004We tested the hypothesis that myocardial stunning would be reduced by increased cyclic GMP and cGMP protein kinase activity. Hearts were instrumented in eight open-chest anesthetized dogs. The left anterior descending coronary artery (LAD) was occluded for 15 minutes followed by a 30-minute recovery and infusion of 8-Bromo-cGMP (0.1 and 1 microg/kg/min)
Qihang, Zhang +6 more
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Annual Review of Neuroscience, 1986
Cyclic GMP is central to visual excitation in vertebrate retinal rod cells. Sodium channels in the plasma membrane of the outer segment are kept open in the dark by a high level of cGMP. Light closes these channels by activating an enzymatic cascade that leads to the rapid hydrolysis of cGMP. Photoexcited rhodopsin triggers transducin by catalyzing the
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Cyclic GMP is central to visual excitation in vertebrate retinal rod cells. Sodium channels in the plasma membrane of the outer segment are kept open in the dark by a high level of cGMP. Light closes these channels by activating an enzymatic cascade that leads to the rapid hydrolysis of cGMP. Photoexcited rhodopsin triggers transducin by catalyzing the
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Clinical Relationships of Cyclic GMP
1994Publisher Summary The purpose of this chapter is to review current knowledge on the clinical use of cyclic guanosine monophosphate (cGMP) measurements as markers of endogenous and exogenous ANP effects. cGMP production through the stimulation of particulate guanylate cyclase is induced by the action of atrial natriuretic peptide (ANP) on target cells.
J R, Cusson +5 more
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1994
Publisher Summary This chapter focuses on the lower forms of life—that is, single-celled organisms. It briefly reviews the literature on cyclic guanosine monophosphate (cGMP) in bacteria and then describes two systems that have been studied frequently—the slime mold ( Dictyostelium discoideum ) and the protozoans ( Paramecium and Tetrahymena ). The
J E, Schultz, S, Klumpp
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Publisher Summary This chapter focuses on the lower forms of life—that is, single-celled organisms. It briefly reviews the literature on cyclic guanosine monophosphate (cGMP) in bacteria and then describes two systems that have been studied frequently—the slime mold ( Dictyostelium discoideum ) and the protozoans ( Paramecium and Tetrahymena ). The
J E, Schultz, S, Klumpp
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Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase
Nature, 1990Atrial natriuretic peptide, acting through its second messenger guanosine 3',5'-cyclic monophosphate (cGMP), suppresses Na+ absorption across the renal inner-medullary collecting duct and increases urinary Na+ excretion. Patch clamp studies show that cGMP reduces Na+ absorption by inhibiting an amiloride-sensitive cation channel in the apical membrane.
D B, Light, J D, Corbin, B A, Stanton
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Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis
1994Several of the different PDE isozyme families have the ability in vitro to hydrolyze cGMP. In particular they include the CaM-dependent PDEs, the cGMP-stimulated PDEs, and the cGMP binding, cGMP-specific PDEs. Existing evidence suggests or demonstrates that in different cell types, each of these can be important determinants for the control of cGMP ...
W K, Sonnenburg, J A, Beavo
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Cyclic GMP-regulated cyclic nucleotide phosphodiesterases
Cellular Signalling, 1993D J, Takemoto +3 more
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2017
Guanosine 3′5′ cyclic monophosphate (cGMP) is synthesized by soluble guanylyl cyclase (sGC) when vascular smooth muscle is stimulated with nitric oxide (NO) and nitrovasodilators and by particulate guanylate cyclases (pGC) when stimulated with natriuretic peptides.
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Guanosine 3′5′ cyclic monophosphate (cGMP) is synthesized by soluble guanylyl cyclase (sGC) when vascular smooth muscle is stimulated with nitric oxide (NO) and nitrovasodilators and by particulate guanylate cyclases (pGC) when stimulated with natriuretic peptides.
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Separation of Cyclic GMP and Cyclic AMP
Analytical Biochemistry, 1996S, Villegas, L L, Brunton
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