Results 71 to 80 of about 43,561 (311)

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides

Journal of Oral Microbiology, 2019
Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated molecular patterns (PAMPs).
Samira Elmanfi, Jie Zhou, Herman O. Sintim, Eija Könönen, Mervi Gürsoy, Ulvi Kahraman Gürsoy   +5 more
doaj   +1 more source

Visualization of c-di-GMP in multicellular Dictyostelium stages

Frontiers in Cell and Developmental Biology, 2023
The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) is only synthesized and utilized by the cellular slime mold Dictyostelium discoideum among eukaryotes.
Hayato Ide, Yukihisa Hayashida, Yusuke V. Morimoto, Yusuke V. Morimoto   +3 more
doaj   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Functional Specialization in Vibrio cholerae Diguanylate Cyclases: Distinct Modes of Motility Suppression and c-di-GMP Production

mBio, 2019
Vibrio cholerae biofilm formation and associated motility suppression are correlated with increased concentrations of cyclic diguanylate monophosphate (c-di-GMP), which are in turn driven by increased levels and/or activity of diguanylate cyclases (DGCs).
David Zamorano-Sánchez, Wujing Xian, Calvin K. Lee, Mauro Salinas, Wiriya Thongsomboon, Lynette Cegelski, Gerard C. L. Wong, Fitnat H. Yildiz   +7 more
doaj   +1 more source

Measuring Individual Cell Cyclic di-GMP: Identifying Population Diversity and Cyclic di-GMP Heterogeneity

, 2020
Cyclic di-GMP is a second messenger used by bacteria to regulate motility, extracellular polysaccharide production, and the cell cycle. Recent advances in the measurement of real time cyclic di-GMP levels in single cells have uncovered significant ...
Miller, Samuel I., Erik Petersen, Petersen, Erik, Samuel I. Miller   +3 more
core   +1 more source

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. [PDF]

, 2012
The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, the kinase TBK1 and the transcription factor IRF3.
Ouyang, Songying, Zhiqiang Zhang, Iyer, Shankar S, Schenk, Mirjam, Liu, Zhi-Jie, Zhong, Wenwan, Parvatiyar, Kislay, Mirjam Schenk, Yong-jun Liu, Zaver, Shivam A, Kislay Parvatiyar, Liu, Yong-jun, Genhong Cheng, Jiang, Yan, Zeng, Shang, Modlin, Robert L, Songying Ouyang, Yan Jiang, Wenwan Zhong, Cheng, Genhong, Teles, Rosane M, Robert L Modlin, Zhi-Jie Liu, Shivam A Zaver, Shang Zeng, Rosane M Teles, Zhang, Zhiqiang, Shankar S Iyer   +27 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349 [PDF]

, 2013
In Burkholderia cenocepacia, the second messenger cyclic diguanosine monophosphate (c-di-GMP) has previously been shown to positively regulate biofilm formation and the expression of cellulose and type-I fimbriae genes through binding to the ...
Ryan, Robert P, Givskov, Michael, Fazli, Mustafa, Tolker-Nielsen, Tim, McCarthy, Yvonne   +4 more
core   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source