Results 101 to 110 of about 62,432 (257)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia

Brain Research Bulletin, 2009
Cyclic nucleotides mediate transient as well as plastic cellular responses. The most ultimate response is cell death. In the present study, we propose that an increase of intracellular cyclic guanosine monophosphate (cGMP) for at least 1h promotes cell death in the murine microglial cell line, BV-2 cells, as well as in primary murine microglia.
Birgit, Nimmervoll, Nina, Svoboda, Beata, Sacha, Hubert H, Kerschbaum   +3 more
openaire   +2 more sources

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

Artificial Organs, EarlyView.
This study aimed to investigate the influence of warm ischemic injury on renal vascular responsiveness to vasoactive drugs during normothermic machine perfusion (NMP). We found that the vascular responses to dopamine and norepinephrine could be used as objective indicators to assess kidney viability during NMP.
Isa M. van Tricht, Baran Ogurlu, Silke S. M. Wolfswinkel, Henri G. D. Leuvenink, Cyril Moers   +4 more
wiley   +1 more source

Regulation Of Epidermal Proliferation And Differentiation In Psoriasis [PDF]

, 1978
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111132/1/jde01861 ...
Voorhees, John J.
core   +1 more source

Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini‐Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim Medical gases, including nitric oxide, carbon monoxide, hydrogen sulphide and molecular hydrogen, have emerged as key regulators of redox balance and cellular signalling. This mini‐review examines their relevance to paediatric endocrine and neurodevelopmental pathways, domains particularly sensitive to oxidative and inflammatory ...
Roberto Paparella, Fabiola Panvino, Ida Pucarelli, Luigi Tarani   +3 more
wiley   +1 more source

Stimulation of Measles Virus Replication by Cyclic Guanosine Monophosphate

Intervirology, 1991
Measles virus (MV) replication in acutely infected human cells was markedly stimulated following exposure to guanosine 3',5'-monophosphate (cyclic GMP). Addition of cyclic GMP to tissue culture fluids immediately following infection with the virus resulted in acceleration of virus-mediated cell fusion, increased synthesis of virus-specified proteins ...
openaire   +2 more sources

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Research progress of phosphodiesterase 5 in heart failure [PDF]

Jichu yixue yu linchuang
Phosphodiesterase 5 (PDE5), a cyclic guanosine monophosphate (cGMP)-specific hydrolase, is targets cGMP produced by soluble guanosine cyclase (sGC) that is activated by nitric oxide (NO). It catalyzes the hydrolysis of the phosphodiester bond in cGMP and
YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The efficient synthesis and purification of 2′3’- cGAMP from Escherichia coli

Frontiers in Microbiology
Agonists of the stimulator of interferon genes (STING) pathway are being explored as potential immunotherapeutics for the treatment of cancer and as vaccine adjuvants for infectious diseases.
Rohan Kulkarni, Vijay Maranholkar, Nam Nguyen, Patrick C. Cirino, Richard C. Willson, Navin Varadarajan   +5 more
doaj   +1 more source