Results 121 to 130 of about 37,981 (210)

Cyclic guanosine monophosphate as a mediator of vasodilation. [PDF]

Journal of Clinical Investigation, 1986
openaire   +2 more sources

Working So Hard: Double‐Stranded RNAs That Can Perform Both Gene Activation and Gene Silencing

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Working so hard: STING saRNAs are capable of not only entering the nucleus to induce subsequent target gene upregulation, but can also act as an siRNA to perform gene silencing. Chemical modifications in saRNA guide and passenger strands affect the strength of gene activation or gene silencing activity.
Virginia Wing‐Nam Chiu, Matthew Lawrence Hammill, Marwah Elabed, Sierra Varley, Yulia Lomonosova, Joseph Hoare, Jon Voutila, Henrik Hansen, Troels Koch, Jean‐Paul Desaulniers   +9 more
wiley   +1 more source

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia-Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate. [PDF]

Front Physiol, 2022
Kuzmiszyn AK, Selli AL, Smaglyukova N, Kondratiev T, Fuskevåg OM, Lyså RA, Ravna AW, Tveita T, Sager G, Dietrichs ES.   +9 more
europepmc   +1 more source

Updates on intratumoral therapies in melanoma

Cancer, Volume 132, Issue 13, 1 July 2026.
Abstract Intratumoral therapies provide an opportunity for novel strategies in the management of advanced melanoma. These approaches deliver concentrated doses of therapeutic immune agents directly into individual tumor(s), achieving local tumor control and induction of systemic antitumor immune responses while minimizing the risk of immune‐related ...
Vincent T. Ma, Alyssa K. Steimle, Janmesh D. Patel, Caroline Burkey, Justin C. Moser, Asad Javed, Hibba tul Rehman, Mustafa Ege Seker, Alexander Birbrair, Orhan S. Ozkan, Mark R. Albertini, Yana G. Najjar, Rajan P. Kulkarni   +12 more
wiley   +1 more source

Plasma Cyclic Guanosine Monophosphate Is a Promising Biomarker of Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis. [PDF]

Front Med (Lausanne), 2021
Sturm L, Bettinger D, Roth L, Zoldan K, Stolz L, Gahm C, Huber JP, Reincke M, Kaeser R, Boettler T, Kreisel W, Thimme R, Schultheiss M.   +12 more
europepmc   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

ABCD of the phosphodiesterase family: interaction and differential activity in COPD

International Journal of COPD, 2008
David MG HalpinRoyal Devon and Exeter Hospital, Exeter, EX2 5DW, UKAbstract: Phosphodiesterases (PDEs) are important enzymes that hydrolyze the cyclic nucleotides adenosine 3′5′-cyclic monophosphate (cAMP) and guanosine 3′5 ...
David MG Halpin
doaj  

Urinary cGMP (Cyclic Guanosine Monophosphate)/BNP (B-Type Natriuretic Peptide) Ratio, Sacubitril/Valsartan, and Outcomes in Heart Failure With Reduced Ejection Fraction: An Analysis of the PARADIGM-HF Trial. [PDF]

Circ Heart Fail, 2023
Butt JH, Ibrahim W, Dewan P, Desai AS, Køber L, Prescott MF, Lefkowitz MP, Rouleau JL, Solomon SD, Zile MR, Packer M, Jhund PS, McMurray JJV.   +12 more
europepmc   +1 more source

Oligomerization of Non‐Activated Nucleotides Under Hot Acidic Wet–Dry Cycling Without Catalytic Agents

ChemSystemsChem, Volume 8, Issue 4, July 2026.
Oligonucleotides form spontaneously through hot wet‐dry cycling of pure non‐activated nucleotides. No catalytic agents were added, and pH was naturally buffered by the nucleotides. Oligonucleotide formation was confirmed and quantified using mass spectrometry, spectroscopy and electrophoresis, establishing a solid baseline for the intrinsic extent of ...
Simon H. J. Eiby, Morten J. Bjerrum, Bálint Hajdu, Laura Da Silva, Peter W. Thulstrup, Tue Hassenkam   +5 more
wiley   +1 more source

Cyclic guanosine monophosphate–dependent protein kinase (PKG); cyclic guanosine monophosphate phosphodiesterase (cGMP-PDE) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source