Results 141 to 150 of about 38,088 (227)

<i>Geum japonicum</i> Thunb. exhibits anti-platelet activity via the regulation of cyclic guanosine monophosphate. [PDF]

Front Pharmacol
Lee YY, Akram AW, Kim YH, Irfan M, Kim SD, Saba E, Kim TW, Yun BS, Rhee MH.   +8 more
europepmc   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Spectrofluorimetric determination of cyclic guanosine monophosphate in human nasal secretions: evaluating levels in healthy individuals and patients with olfactory dysfunction. [PDF]

BMC Chem
Abdelazim MH, Alsenani F, Alharbi A, Baali FH, Baali AH, Abduljabbar MH, Alnemari RM, Algarni MA.   +7 more
europepmc   +1 more source

A Physiologically Based Pharmacokinetic Model to Predict Potential Drug–Drug Interactions of TPN171, a Novel Phosphodiesterase Type 5 Inhibitor

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT TPN171 is a potent phosphodiesterase type 5 inhibitor used to treat pulmonary arterial hypertension and erectile dysfunction, primarily metabolized by CYP3A4. This study aimed to evaluate its drug–drug interaction (DDI) potential and determine the optimal dosing when co‐administered with CYP3A4 modulators.
Guanghui Tian, Tao Chen, Lei Li, Zhiqiang Wang, Hao Yang, Jiaxiang Juan, Yuanqin Duan, Jianghong Pei, Jingying Jia   +8 more
wiley   +1 more source

Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia–Reperfusion Injury and Atherosclerosis Development

Phytotherapy Research, Volume 40, Issue 8, Page 5299-5315, August 2026.
Schematic representation of the experimental design and the proposed mechanisms underlying the cardioprotective and anti‐atherosclerotic effects of Greek‐derived berry extracts. C57BL/6 mice with WD–induced MS and ApoE−/− mice with atherosclerosis received chronic supplementation with WMex or BBex.
Lydia Symeonidi, Panagiota‐Efstathia Nikolaou, Panagiotis Stathopoulos, Andriana Christodoulou, Alexandra Svouraki, Panagiotis Efentakis, Christina Chania, Angeliki Choustoulaki, Maria Xenaki, Anna Agapaki, Maria Tsoumani, Nikolaos Kostomitsopoulos, Ioulia Tseti, Gemma Vilahur, Alexios‐Leandros Skaltsounis, Ioanna Andreadou   +15 more
wiley   +1 more source

Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons. [PDF]

Integr Org Biol, 2021
Pirtle TJ, Satterlie RA.
europepmc   +1 more source

Revisiting Controversial Areas in the Management of Premature Ejaculation

Trends in Urology &Men's Health, Volume 17, Issue 4, August 2026.
ABSTRACT The cause of premature ejaculation (PE) is often multifactorial in nature, and effective management of PE is complex and should involve multimodal approaches. This narrative review examines the ongoing controversies surrounding key areas in the diagnosis and treatment of PE with an emphasis on future research directions to align clinical care ...
Dong Sup Lee, Min Gu Park, Sun Tae Ahn, Ho Seok Chung, Hwancheol Son, Hyun Jun Park, Eric Chung   +6 more
wiley   +1 more source

Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma. [PDF]

World J Gastrointest Oncol
Nie AY, Xiao ZH, Deng JL, Li N, Hao LY, Li SH, Hu XY.   +6 more
europepmc   +1 more source

Elevated LncRNA LINC00966 Suppresses PDE2A to Impair Sperm Motility in Asthenozoospermia

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
This study identifies LINC00966 as an upregulated lncRNA in asthenozoospermia associated with reduced sperm quality. Linc00966 suppresses Pde2a, disrupts cGMP signaling, and promotes oxidative stress, thereby impairing spermatogenic cell viability and migration.
Bingrou Guo, Junyi Ke, Hanran Mai, Ting Zhang, Zhaojin Lu, Zilin Zheng, Jieyi Luo, Yifan Zhang, Mei Yan, Shuo Yang, Yanxia Qu, Fan Jiang, Xiaoping Liu, Hao Chen, Liandong Zuo   +14 more
wiley   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source