Results 101 to 110 of about 433,779 (173)

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, Volume 16, Issue 10, Page 1958-1973, October 2026.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Selective Partition of Lipopeptides from Fermentation Broth: A Green and Sustainable Approach

, 2022
Lipopeptide (LP) biosurfactants from microbes have the potential to gradually replace chemical synthetic surfactants and fit the contemporary green and sustainable industrial production concept. However, their active participation is comparatively low in
Pankaj Kumar (63234), Vishal A. Ghadge (14241081), Arup Ghosh (643530), Pradipkumar Vaghela (14241084), Kamalesh Prasad (1519336), Ajeet Kumar Mohanty (8724486), Rosy Alphons Sequeira (3850267), Sanju Singh (8980376), Pramod B. Shinde (1941844)   +8 more
core   +1 more source

From Rhizosphere to Resistance: Microbe‐Plant Interactions in Eco‐Smart Biocontrol

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Conceptual framework of eco‐smart biocontrol: Root exudates released by plants shape rhizosphere microbial community assembly by selectively recruiting beneficial microorganisms. These microbes suppress phytopathogens through direct mechanisms such as antibiosis, parasitism, enzyme production, and niche competition, while simultaneously activating ...
Shilpy Singh, Varun Kumar Sharma, Dharmsheel Shrivastav, Jayant M. Kushwaha, Manoj Kumar Mishra, Mirza Masroor Ali Beg   +5 more
wiley   +1 more source

Glucose-Induced Cyclic Lipopeptides Resistance in Bacteria via ATP Maintenance through Enhanced Glycolysis

iScience, 2019
Summary: Cyclic lipopeptide (CLP) antibiotics have a mechanism that causes membrane malfunction. Thus mechanisms of bacterial resistance to CLPs are thought to modify cell surfaces. However, we found that bacterial resistance to CLPs was strongly related
Wen-Bang Yu, Qian Pan, Bang-Ce Ye
doaj   +1 more source

Serious staphylococcal infections—cyclic lipopeptides: meeting new challenges [PDF]

Clinical Microbiology and Infection, 2008
This supplement is based on the proceedings of the symposium entitled ‘Serious staphylococcal infections—cyclic lipopeptides: meeting new challenges’, which was presented at the 17th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Munich during April 2007.
openaire   +2 more sources

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

In vitro and in vivo activities of novel cyclic lipopeptides against staphylococcal biofilms

, 2014
A worldwide public health problem has resulted from the alarming spread of multi-drug resistant bacteria combined with the frequent occurrence of biofilm-type infections, creating a growing need for new therapies. In this study, we have demonstrated that
Bionda, Nina, Davis, Stephen C, Pastar, Irena, Cudic, Predrag   +3 more
core   +1 more source

Characterization of lpaH2 gene corresponding to lipopeptide synthesis in Bacillus amyloliquefaciens HAB-2

BMC Microbiology, 2017
Background Bacillus spp. have prominent ability to suppress plant pathogens and corresponding diseases. Previous analyses of Bacillus spp. revealed numerous gene clusters involved in nonribosomal synthesis of cyclic lipopeptides with distinct ...
Pengfei Jin, Haonan Wang, Wenbo Liu, Weiguo Miao   +3 more
doaj   +1 more source

Ion mobility mass spectrometry for lipopeptides analysis

, 2019
Cyclic lipopeptides (CLPs) are produced by bacteria in a ribosome independent manner and consists in a hydrophilic peptide linked to a B-hydroxy fatty acid chain.
De Pauw, Edwin, Quinton, Loïc, Kune, Christopher, Massonnet, Philippe, Mc Cann, Andréa, Far, Johann, Eppe, Gauthier   +6 more
core   +1 more source