Results 131 to 140 of about 433,779 (173)

Predicting the Structure of Cyclic Lipopeptides by Bioinformatics: Structure Revision of Arthrofactin

ChemBioChem, 2012
Arthrofactin, a bioactive cyclic lipopeptide from Pseudomonas sp. MIS38, was reinvestigated for its structural and stereochemical features due to discrepancies between the genetics-based sequence prediction and the currently suggested structure. The structure of arthrofactin and its derivatives was reassigned on the basis of chiral HPLC analysis and ...
Anna Lange, Harald Groß, Han Sun
exaly   +5 more sources

WH1fungin a surfactin cyclic lipopeptide is a novel oral immunoadjuvant

Vaccine, 2013
WH1fungin, a surfactin lipopeptide from Bacillus amyloliquefaciens WH1, can be used as an adjuvant for eliciting strong immune response by parenteral immunization. In this study, WH1fungin was firstly reported as an oral immunoadjuvant. In mice, WH1fungin markedly enhanced the immune response to co-administered protein antigens (OVA or GST), similar to
Zhenqiu, Gao, Xiuyun, Zhao, Song, Lee, Jingjing, Li, Hao, Liao, Xiaohui, Zhou, Jie, Wu, Gaofu, Qi   +7 more
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Production of Cyclic Lipopeptides by Fluorescent Pseudomonads

2004
Members of the genus Pseudomonas produce a large amount of metabolites that are released into the extracellular environment. Among these metabolites are siderophores, phytohormones, biosurfactants and several antibiotic compounds, which may have broad-spectrum activity24, 81.
Nybroe, O, Sørensen, J
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Cyclic Lipopeptide Antibiotics

2008
Abstract Numerous natural products have been discovered, mainly from microorganisms, algae and plants, that often exhibit interesting and useful biological activities. Of these, cyclic lipopeptide antibiotics form the biggest group and provide several clinically important drugs.
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[Oxazolidinones, glycopeptides and cyclic lipopeptides].

Enfermedades infecciosas y microbiologia clinica, 2009
A review of the chemical structure, pharmacokinetics, spectrum of activity, clinical use, and adverse effects of oxazolidinones (linezolid), glycopeptides, and cyclic lipopeptides (daptomycin) is presented. Oxazolidinones inhibit protein synthesis, and glycopeptides and cyclic lipopeptides act against the bacterial cell wall. The antibacterial spectrum
Carlos, Pigrau, Benito, Almirante
openaire   +1 more source

Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics

Journal of Medicinal Chemistry, 2018
In this paper, 26 natural polymyxin components and a new derivative S2 were synthesized, and their differences in efficacy and toxicity have been investigated. Almost all of the synthesized components showed strong activity against both susceptible and resistant strains of E. coli, K. pneumoniae, P. aeruginosa, and A. baumannii.
A-Long Cui, Xin-Xin Hu, Yan Gao, Jie Jin, Hong Yi, Xiu-Kun Wang, Tong-Ying Nie, Yang Chen, Qi-Yang He, Hui-Fang Guo, Jian-Dong Jiang, Xue-Fu You, Zhuo-Rong Li   +12 more
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[Progress on the studies of cyclic lipopeptides].

Yao xue xue bao = Acta pharmaceutica Sinica, 2009
Cyclic lipopeptide, also named as acylpeptide, which was characteristic with novel structures, was paid more attention in the recent years. Cyclic lipopeptide showed various bioactivities including antibacterial, anti-tumor, anti-inflammatory, etc. Cyclic lipopeptide originated mainly from the second metabolites of microorganism, such as Cyanobacterium,
Jin-shan, Tang, Hao, Gao, Yi, Dai, Kui, Hong, Xin-sheng, Yao   +4 more
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Cyclic lipopeptides as interface modulation in nano soft – Delivery

Advances in Colloid and Interface Science
Owing to their distinct properties, carriers of active compounds are gaining increasing interest not only in the pharmaceutical industry, but also in the food, dietary supplement, and cosmetics sectors. The concept of encapsulating active molecules within nanoparticles enables the enhancement of their activity, bioavailability, and stability, as well ...
Michał, Bochynek, Marta, Domżał-Kędzia, Agnieszka, Lewińska   +2 more
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Synthesis and antifungal activities of cyclic octa-lipopeptide burkholdine analogues

Bioorganic & Medicinal Chemistry Letters, 2013
Synthesis and antifungal activity of cyclic octapeptide derivatives of burkholdines are described. To construct cyclic octapeptides, the combination of Fmoc-SPPS and cyclization with DIC/HOBt in the solution phase was employed. Synthesized peptides were evaluated for antifungal activity with MIC values against Saccharomyces cerevisiae, Aspergillus ...
Hiroyuki, Konno, Yusuke, Otsuki, Kenta, Matsuzaki, Kazuto, Nosaka   +3 more
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A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides

Organic & Biomolecular Chemistry, 2013
A concise solid-phase synthesis of cyclic lipopeptides derived from the antimicrobial peptide c(Lys-Lys-Leu-Lys-Lys-Phe-Lys-Lys-Leu-Gln) (BPC194) was accomplished. Three different synthetic routes were explored. Best results were obtained using a protocol that includes as key steps: (i) synthesis of the cyclic peptidyl resin incorporating the Lys ...
Sílvia, Vilà, Esther, Badosa, Emilio, Montesinos, Lidia, Feliu, Marta, Planas   +4 more
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