Results 121 to 130 of about 90,964 (311)

Fatigue crack growth rates under variable amplitude load spectra containing tensile underloads [PDF]

, 2003
An extensive research program was performed to investigate the load interaction effect of the combined action of small amplitude high R ratio cycles and large amplitude low R ratio underloads on the crack growth of large cracks.
Zitounis, Vasilios
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analysis of fracture deformation field and energy evolution of granite after high confining pressure cyclic load pre-damage. [PDF]

R Soc Open Sci, 2021
Yang D, Hu J, Wen G, Zeng P.
europepmc   +1 more source

Cyclic Distributed Garbage Collection with Group Merger

, 1997
This paper presents a new algorithm for distributed garbage collection and outlines its implementation within the Network Objects system. It supersedes the earlier version, /pubs/1997/548. The algorithm is based on a reference listing scheme augmented by
Helena Rodrigues, Jones, Richard E., Rodrigues, Helena, Rodrigues, Helena C.C.D., Jones, Richard, Richard Jones   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Continuous cyclic load reduces proteoglycan release from articular cartilage

, 1998
Objective: to study the effect of a continuous cyclic mechanical load on the release of newly synthesized proteoglycans (PGs) from mature bovine articular cartilage.Methods: Viable cartilage explants were continuously loaded with 1 MPa cyclic stress at 1
Grigiene, Rita, Torzilli, Peter A.
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Monitoring random vehicle load information-based time-varying reliability analysis of PC bridge considering concrete cyclic creep effects

Advances in Bridge Engineering
During the long-term service periods of Prestressed Concrete(PC) continuous girder bridges, structural time-varying reliability will degrade due to cyclic creep induced by dynamic vehicle loading, which increases the risk of structural failure.
Qifan Zhao, Yuefei Liu, Xueping Fan
doaj   +1 more source

Effective Stress-Based Numerical Method for Predicting Large-Diameter Monopile Response to Various Lateral Cyclic Loadings

Journal of Marine Science and Engineering
Extreme marine environmental cyclic loading significantly affects the serviceability of monopiles applied for the foundation of offshore wind turbines (OWTs).
Jichao Lei, Kehua Leng, Wei Xu, Lixian Wang, Yu Hu, Zhen Liu   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source