Results 101 to 110 of about 90,964 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Cyclic settlement behavior of strip footings resting on reinforced layered sand slope

Journal of Advanced Research, 2012
The paper presents a study of the behavior of model strip footings supported on a loose sandy slope and subjected to both monotonic and cyclic loads.
Mostafa A. El Sawwaf, Ashraf K. Nazir
doaj   +1 more source

Study on Dynamic Modulus and Damping Characteristics of Modified Expanded Polystyrene Lightweight Soil under Cyclic Load. [PDF]

Polymers (Basel), 2023
Tao H, Zheng W, Zhou X, Zhou L, Li C, Yu Y, Jiang P.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Nonlinear Analytical Procedure for Predicting Debonding of Laminate from Substrate Subjected to Monotonic or Cyclic Load. [PDF]

Materials (Basel), 2022
Lamberti M, Ascione F, Napoli A, Razaqpur G, Realfonzo R.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effect of Sulfate Concentration on Chloride Diffusion of Concrete under Cyclic Load. [PDF]

Materials (Basel), 2022
Yu D, Feng C, Fu T, Shen A.
europepmc   +1 more source

Constitutive modelling of the behaviour of clays under cyclic loading

, 1989
Includes bibliography.This research work involved the implementation of a constitutive model based on plasticity theory to model the behaviour of a clay under cyclic loading.
Sellers, E J
core  

A fully implicit, lower bound, multi-axial solution strategy for direct ratchet boundary evaluation : theoretical development

, 2013
Ensuring sufficient safety against ratchet is a fundamental requirement in pressure vessel design. Determining the ratchet boundary can prove difficult and computationally expensive when using a full elastic-plastic finite element analysis and a number ...
Jappy, Alan, Chen, Haofeng, Mackenzie, Donald   +2 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source