Results 81 to 90 of about 70,301 (265)

Resilient Response of Cement-Treated Coarse Post-Glacial Soil to Cyclic Load. [PDF]

Materials (Basel), 2021
Zabielska-Adamska K, Wasil M, Dobrzycki P.   +2 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Rheological Model to Describe the Cyclic Load-Bearing Behaviour of Strain-Hardening Cement-Based Composites (SHCC). [PDF]

Materials (Basel), 2021
Junger D, Müller S, Mechtcherine V.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Settlement of a silo subjected to cyclic loading

, 1994
The paper presents the vertical settlement values for a corn silo located at Ca' Mello, close to Porto Tolle (Italy), and compares it with the theoretical results obtained using a simplified one-dimensional consolidation theory, under cyclic tirangulard-shaped loading. Settlements of the silo's lateral sides range between two extremes, corresponding to
MAZZUCATO, ALBERTO, M. FAVARETTI
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effective Stress-Based Numerical Method for Predicting Large-Diameter Monopile Response to Various Lateral Cyclic Loadings

Journal of Marine Science and Engineering
Extreme marine environmental cyclic loading significantly affects the serviceability of monopiles applied for the foundation of offshore wind turbines (OWTs).
Jichao Lei, Kehua Leng, Wei Xu, Lixian Wang, Yu Hu, Zhen Liu   +5 more
doaj   +1 more source

A finite element analysis and cyclic load experiment on an additional transcortical-type hole formed around the proximal femoral nail system's distal locking screw. [PDF]

BMC Musculoskelet Disord, 2022
Cho HM, Choi SM, Park JY, Lee Y, Bae JH.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analysis of fracture deformation field and energy evolution of granite after high confining pressure cyclic load pre-damage. [PDF]

R Soc Open Sci, 2021
Yang D, Hu J, Wen G, Zeng P.
europepmc   +1 more source