Results 81 to 90 of about 90,964 (311)

Dynamic Behaviours of a Single Soft Rock-Socketed Shaft Subjected to Axial Cyclic Loading

Advances in Materials Science and Engineering, 2016
The soft rock was simulated by cement, plaster, sand, water, and concrete hardening accelerator in this paper. Meanwhile, uniaxial compressive strength tests and triaxial compression tests were conducted to study the mechanical properties of simulated ...
Ben-jiao Zhang, Bin Huang, Can Mei, Xu-dong Fu, Gang Luo, Zhi-jun Yang   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Linear matching method for design limits in plasticity

, 2010
In this paper a state-of-the-art numerical method is discussed for the evaluation of the shakedown and ratchet limits for an elastic-perfectly plastic body subjected to cyclic thermal and mechanical load history. The limit load or collapse load, i.e. the
Chen, Haofeng
core  

Cyclic plastic deformation characteristics of subgrade under moving train wheel load

, 2015
Cyclic plastic deformation of subgrade and other engineered layers is generally not taken into account in the design of railway bridge transition zones, although the plastic deformation is the governing factor of frequent track deterioration.
Gallage, Chaminda, Dareeju, Biyanvilage, Ishikawa, Tatsuya, Dhanasekar, Manicka   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ratchet limits for a crack in a welded pipe subjected to a cyclic temperature load an a constant mechanical load

, 2011
This paper presents the ratchet limit analysis of a pipe with a symmetric crack in a mismatched weld by using the extended Linear Matching Method (LMM). Two loading conditions are considered: i) a cyclic temperature load and a constant internal pressure;
Ure, James Michael, Chen, Haofeng, Li, Tianbai, Chen, Weihang   +3 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Nonlinear modeling of the cyclic response of RC columns

, 2012
Cyclic load reversals (like those induced by earthquakes) result in accelerated bond degradation, leading to significant bar slippage. The bond-slip mechanism is reported to be one of the most common causes of damage and even collapse of existing RC ...
Costa, A., Melo, J., Varum, H., Fernandes, C., Rossetto, T.   +4 more
core  

Numerical simulation of ratcheting and fatigue behaviour of mitred pipe bends under in-plane bending and internal pressure

, 2013
This paper investigates the ratcheting and fatigue behaviour of 90 degree single unreinforced mitred pipe bends subjected to a cyclic in-plane closing moment with a non-zero mean value and constant internal pressure. An experiment was conducted to induce
Wood, James, McCormack, Ross, Li, Hongjun, Hamilton, Robert   +3 more
core   +1 more source