Results 61 to 70 of about 90,964 (311)
REINFORCED CONCRETE UNDER CYCLIC LOADING
, 2000 In order to contribute to the on going research effort in this field, an experimental working plan with cylinder steel fibre reinforced concrete specimens under compression cyclic loading was carried out. Sets of five specimens were reinforced with conventional transverse reinforcement of 0, 0.57, 1.71 and 4.01 volume percentage of specimen concrete ...
Barros, Joaquim A. O. +3 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2011 In this study, the limit load, shakedown and ratchet limit of a defective pipeline subjected to constant internal pressure and a cyclic thermal gradient are analyzed.
Ure, James Michael +8 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Use of Blind Rivets in Sandwich Panels—Experimental Investigation of Static and Quasi-Cyclic Loading
Buildings, 2020 In this paper, we present an original experimental investigation on a pull-out test of a blind rivet from the external facing of sandwich panels with various core layer materials (polyisocyanurate foam, mineral wool, and expanded polystyrene).
Robert Studziński +1 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Structural integrity assessment of superheater outlet penetration tubeplate
, 2009 In recent years, the Linear Matching Method (LMM) has been well developed for the integrity assessment of the component subjected to cyclic thermal and mechanical loads.
Haofeng Chen +3 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Linear matching method on the evaluation of cyclic behaviour with creep effect
, 2012 This paper describes a new Linear Matching Method (LMM) technique for the direct evaluation of cyclic behaviour with creep effects of structures subjected to a general load condition in the steady cyclic state.
Ure, James Michael +2 more
core