Results 51 to 60 of about 90,964 (311)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Lateral Cyclic Loading of Sand-Installed Piles
Soils and Foundations, 2007 The present study was conducted to examine the behaviour of instrumented flexible piles in dry sand under lateral cyclic loading using centrifuged models. Considering load service conditions, the influence of the number of cycles of their amplitude and of the soil density on the pile cap displacement and the maximum bending moment of the pile is ...
Rosquoet, Frédéric +3 more
openaire +3 more sources
, 2006 Design and life assessment procedures for high temperatures are based on 'expert knowledge' in structural mechanics and materials science, combined with simplified methods of structural analysis. Of these R5 is one of the most widely used life assessment
Chen, Haofeng +2 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
On shakedown, ratchet and limit analysis of defective pipeline
, 2011 In this study, the limit load, shakedown and ratchet limit of a defective pipeline subjected to constant internal pressure and a cyclic thermal gradient are analyzed.
Ure, James Michael +7 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
GeotechnicsThe amount of energy dissipated in the soil during cyclic loading controls the amount of pore pressure generated under that loading. Because of this, the normalized dissipated energy per unit volume is the basis for both pore pressure generation models ...
Carmine P. Polito +2 more
doaj +1 more source
International Journal of Distributed Sensor Networks, 2019 Understanding the acoustic emission effects on bolts under cyclic loading is of great significance for the support of roadways. The presented research focuses on the acoustic emission characteristics of bolts under cyclic loading.
Tieliang An +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source