Results 101 to 110 of about 372,306 (310)

Analysis of permeability evolution law of gas-bearing coal under cyclic loading condition

Meitan kexue jishu
In order to explore the permeability evolution law of gas-bearing coal under different cyclic loading and unloading conditions, raw coal samples were taken as the research object, and cyclic loading-unloading experiments of gas-bearing coal were designed
Dengke WANG, Haohang FENG, Jianping WEI, Xu CHEN, Zhigang JIANG, Xiuzhu YUAN, Yun BAI, Tanggen CAO, Wenchao XIONG   +8 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A New Method for Predicting Dynamic Pile Head Stiffness Considering Pile–Soil Relative Stiffness Under Long-Term Cyclic Loading Conditions

Buildings
Under long-term horizontal cyclic loading, the evolution characteristics of the loading and unloading stiffness of piles are an important representation of pile–soil interaction.
Jie Chen, Jiaqing Shu, Shuang Xi, Xiaoqing Gu, Mingxing Zhu, Xiaojuan Li   +5 more
doaj   +1 more source

Effect of Cyclic Loading on the Elasticity of Beech Solid and Laminated Wood

BioResources, 2014
This article deals with the determination of the cyclic loading effect on the elastic modulus (Em) of beech solid and laminated wood at various thicknesses while bent in the radial direction.
Milan Gaff, Jozef Gáborík
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Development of rock creep test system considering dynamic-static and ultralow-frequency cyclic loading

Journal of Rock Mechanics and Geotechnical Engineering
This paper presents an ultralow-frequency cyclic loading creep test system for rock salt. The system comprises five subsystems: a cyclic load generation system, a triaxial pressure chamber, a pressure and deformation monitoring system, a signal ...
Yinping Li, Zhikai Dong, Xilin Shi, Haoran Li, Cuiyao Zhuo, Yuanxi Liu, Xiangsheng Chen, Si Huang, Weigang Zhao, Yaodong Qi   +9 more
doaj   +1 more source

Behavior of confined granular beds under cyclic thermal loading

, 2019
We investigate the mechanical behavior of a confined granular packing of irregular polyhedral particles under repeated heating and cooling cycles by means of numerical simulations with the Non-Smooth Contact Dynamics method.
Giacomazzi, Elena, Haselbacher, Andreas, Herrmann, Hans J., Iliev, Pavel S., Mendoza, Miller, Wittel, Falk K.   +5 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Behaviour of monopile-gravity-shallow bucket hybrid foundation for offshore wind turbine under cyclic load in sandy soil

Applied Ocean Research
This paper investigates the behavior of a monopile-gravity-shallow bucket (MGB) hybrid foundation for offshore wind turbines (OWTs) under cyclic loading conditions. The study aims to understand the long-term performance of the hybrid foundation, focusing
Xinyao Li, Yi Tan, Yifei Sun, Min Zhang, Wei Duan, Zean Xiao   +5 more
doaj   +1 more source