Results 51 to 60 of about 14,027,089 (269)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Halogen‐Free Anisotropic Atomic‐Layer Etching of HfO2 at Room Temperature

Small Science
Hafnium(IV) oxide (HfO2)‐based materials have attracted substantial interest owing to their outstanding performance in advanced ultrathin semiconductor devices.
Shih‐Nan Hsiao, Pak‐Man Yiu, Li‐Chun Chang, Jyh‐Wei Lee, Makoto Sekine, Masaru Hori   +5 more
doaj   +1 more source

Thermal rearrangements of cyclic amine ylides. IV. Rearrangement of .BETA.,.GAMMA.-unsaturated 1-alkylpiperidine N-oxides: Formation of 1,2-oxazepine derivatives.

Chemical and Pharmaceutical Bulletin, 1984
The thermolysis of 1-methyl-2-vinylpiperidine N-oxide (13) resulted in Meisenheimer [1, 2] rearrangement to give the hexahydro-1, 2-oxazepine (23) and no [2, 3]-sigmatropic rearrangement product (24). Similarly, the 1-methyl-1, 2, 5, 6-tetrahydropyridine N-oxides (15), on heating, gave only the tetrahydro-1, 2-oxazepines (26, 27), together with the ...
SASHIDA, HARUKI, TSUCHIYA, TAKASHI
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Double Group Transfer Reactions of an Unsaturated Tantalum Methylidene Complex with Pyridine N-Oxides

, 2016
The electrophilic nature of the benzamidinate tantalum methylidene complex [TolC(NSiMe3)2]2Ta(CH2)CH3 (1) allows for reactivity with pyridine N-oxides, which leads to the formation of the tantalum oxo complex [TolC(NSiMe3)2]2Ta(O)CH3 (5) and ...
Robert G. Bergman (1323120), Sarah M. Mullins (2964627), John Arnold (1346964)   +2 more
core   +1 more source

Regioselective reaction of heterocyclic N-oxides, an acyl chloride and cyclic thioethers [PDF]

, 2018
Treatment of electron deficient pyridine N-oxides with 4-nitrobenzoyl chloride and a cyclic thioether in the presence of triethylamine leads to the corresponding 2-functionalized product in up to 74% iso-lated yield.
Frei, Przemysslaw, Johnston, Blair F., Tomkinson, Nicholas C. O., Kay, Steven T., Jones, D. Heulyn, Kennedy, Alan R., McLellan, Jayde A.   +6 more
core   +2 more sources

S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET)–Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants: Results and overview

Journal of Pharmaceutical Analysis, 2018
S-Nitrosothiols or thionitrites with the general formula RSNO are formally composed of the nitrosyl cation (NO+) and a thiolate (RS−), the base of the corresponding acids RSH.
Dimitrios Tsikas, Kathrin S. Schwedhelm, Andrzej Surdacki, Daniela Giustarini, Ranieri Rossi, Lea Kukoc-Modun, George Kedia, Stefan Ückert   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source