Results 81 to 90 of about 81,546 (283)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Rearrangement of β-Chloro N-Oxides to Hydroxylamines: Opening of the Oxazetidinium Intermediate by Different Nucleophiles [PDF]

, 2016
The rearrangement of β-chloro N-oxides to hydroxylamines is stereospecific in accord with the presence of a cyclic oxazetidinium intermediate. The latter opens with a range of nucleophiles (carboxylates, cyanide, azide, and thiols)
Ulrike K. Wefelscheid (2388271), Simon Woodward (769318)   +1 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Electronic Environments and Electrochemical Properties in Lithium Storage Materials [PDF]

, 2003
The local electronic environments and energy storage properties of lithium electrodes are investigated through inelastic electron scattering and electrochemical measurements.
Graetz, Jason Allan
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An Eilenberg-Ganea phenomenon for actions with virtually cyclic stabilizers [PDF]

, 2014
In dimension 3 and above, Bredon cohomology gives an acurate purely algebraic description of the minimal dimension of the classifying space for actions of a group with stabilisers in any given family of subgroups.
Martin G. Fluch, Ian J. Leary, Fluch, Martin, Leary, Ian   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Propriétés redox des indolone-N-oxydes et des extraits de crinum latifolium en relation avec leurs propriétés biologiques [PDF]

, 2013
Le travail de thèse porte sur l'examen des liens existants entre les propriétés d'oxydo-réduction de molécules de synthèse (indolone-N-oxydes) et d'extraits naturels (Crinum latifolium) et leurs activités biologiques, respectivement antipaludiques et ...
Nguyen, Thi Hoang Yen
core  

On cyclic 〈m,n〉-enumerations [PDF]

, 2004
A word is called cyclic if each letter occurs in it an even number of times. A cyclic word X on the n-letter alphabet is called a cyclic 〈m,n〉-word if there is a letter in each subword of X occurring in it an odd number of times, and in each subword of X
Perezhogin, A.L
core   +1 more source