Results 101 to 110 of about 44,336 (211)

Generation and phenotypic characterization of Pde1a mutant mice [PDF]

, 2017
Contains fulltext : 177029.pdf (publisher's version ) (Open Access)It has been proposed that a reduction in intracellular calcium causes an increase in intracellular cAMP and PKA activity through stimulation of calcium inhibitable ...
Wang, X., Yamada, S., LaRiviere, W.B., Ye, H., Bakeberg, J.L., Irazabal, M.V., Chebib, F.T., Deursen, J. van, Harris, P.C., Sussman, C.R., Behfar, A., Ward, C.J., Torres, V.E.   +12 more
core   +7 more sources

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.

PLoS Neglected Tropical Diseases, 2020
Only a single drug against schistosomiasis is currently available and new drug development is urgently required but very few drug targets have been validated and characterised.
Jane C Munday, Stefan Kunz, Titilola D Kalejaiye, Marco Siderius, Susanne Schroeder, Daniel Paape, Ali H Alghamdi, Zainab Abbasi, Sheng Xiang Huang, Anne-Marie Donachie, Samia William, Abdel Nasser Sabra, Geert Jan Sterk, Sanaa S Botros, David G Brown, Charles S Hoffman, Rob Leurs, Harry P de Koning   +17 more
doaj   +1 more source

The effects of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons [PDF]

, 1980
Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt.
Benichou, J, Francavilla, A, Jones, AF, Starzl, TE   +3 more
core  

The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]

, 2018
Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
core   +2 more sources

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A? [PDF]

Int J Mol Sci, 2023
Zheng Y, Schroeder S, Kanev GK, Botros SS, William S, Sabra AA, Maes L, Caljon G, Gil C, Martinez A, Salado IG, Augustyns K, Edink E, Sijm M, de Heuvel E, de Esch IJP, van der Meer T, Siderius M, Sterk GJ, Brown D, Leurs R.   +20 more
europepmc   +1 more source

Tissue‐Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri, Erez Eitan, Kenneth W. Witwer, Diane B. Re, Andrea A. Baccarelli, Haotian Wu   +5 more
wiley   +1 more source

Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers. [PDF]

Int J Mol Sci, 2023
Campolo F, Assenza MR, Venneri MA, Barbagallo F.   +3 more
europepmc   +1 more source

Oligodendrocyte: Development, Plasticity, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
The oligodendrocyte lineage and its roles in development, plasticity, and CNS homeostasis have been shown to have the potential to treat neurological diseases. However, the main obstacles to clinical translation, particularly in terms of BBB challenges and precise delivery.
Qiong Xiang, Ruo‐Lan Shi, You‐Xia Huang, Li‐Ni Liu, Jia‐Sheng Tao, Xian‐Hui Li, Xiao‐Da Li   +6 more
wiley   +1 more source

Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors. [PDF]

, 1982
We have measured the levels of 3',5'-guanosine monophosphate (cyclic GMP) in isolated retinas from toad to investigate their correlation to the opening and closing of the light-dependent permeability of photoreceptors. When Ca2+-induced changes in cyclic
Fain, GL, Woodruff, ML
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