Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms. [PDF]
Int J Mol Sci, 2022 Cardarelli S +8 more
europepmc +1 more source
High‐Throughput Screen of NPQ in Sorghum Shows Highly Polygenic Architecture of Photoprotection
Plant-Environment Interactions, Volume 7, Issue 1, February 2026.ABSTRACT Natural genetic variation in photosynthesis and photoprotection within crop germplasm represents an untapped resource for crop improvement. Sorghum bicolor (sorghum) is one of the world's most widely grown crops, yet the genetic basis of photoprotection in sorghum is not well understood.
Richard L. Vath +9 more
wiley +1 more source
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]
, 2013 UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R +6 more
core +2 more sources
Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm. [PDF]
Proc Natl Acad Sci U S A, 2021 Zhang C +11 more
europepmc +1 more source
VIEW, Volume 7, Issue 1, February 2026.This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu +8 more
wiley +1 more source
Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]
, 2014 STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari +54 more
core +5 more sources
An update of cyclic nucleotide phosphodiesterase as a target for cardiac diseases. [PDF]
Expert Opin Drug Discov, 2021 Chen S, Yan C.
europepmc +1 more source
Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 2, February 2026.ABSTRACT This study examined whether CYP1A2 (rs762551) genotype modulates the acute ergogenic effects of caffeine on muscular strength and endurance performance in resistance‐trained men and women. Ninety‐four resistance‐trained participants (47 females, 47 males; 39 AA, 44 AC, 11 CC) completed a randomized, triple‐blind, placebo‐controlled, crossover ...
Juan Jesús Montalvo‐Alonso +5 more
wiley +1 more source
EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis [PDF]
, 2004 BACKGROUND: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro.
Beier, Norbert +2 more
core +2 more sources
Identification and functional study of genetic polymorphisms in cyclic nucleotide phosphodiesterase 3A (PDE3A). [PDF]
Ann Hum Genet, 2021 Kim YR +6 more
europepmc +1 more source