Moracin M derivative targeting PDE4 for the treatment of psoriasis
Acta Materia MedicaPhosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity with PDE4 inhibitors increases intracellular cAMP levels
Liru Chen +8 more
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Isolation of Nuclei from Physarum flavicomum: Demonstration of Nuclear Cyclic Acid AMP Phosphodiesterase [PDF]
, 1986 Cyclic AMP phosphodiesterase activity in the nucleus of the myxomycete Physarum flavicomum was demonstrated by cytochemical staining utilizing electron microscopy and by enzymatic assays with tritiated cyclic AMP as the substrate.
Bean, Judith A. +2 more
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Cyclic nucleotide phosphodiesterases as drug targets
Pharmacological ReviewsCyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick
Michy P. Kelly +28 more
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Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]
, 1994 Forssmann, W. G. +6 more
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Involvement of cyclic AMP in multiple, excitatory actions of biogenic amines on the cardiac ganglion of the horseshoe crab Limulus polyphemus [PDF]
, 1990 Cyclic AMP appears to be involved in several excitatory actions of amines on neurones of the Limulus cardiac ganglion. Amines selectively increase levels of cardiac ganglion cyclic AMP with a magnitude and time course similar
Groome, J. R., Watson, Winsor H., III
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Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages
Applied SciencesCyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation.
Simona Todisco +8 more
doaj +1 more source
Response by Chen and Yan to Letter Regarding Article, "A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction". [PDF]
Circulation, 2020 Chen S, Yan C.
europepmc +1 more source
A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction. [PDF]
Circulation, 2020 Chen S +7 more
europepmc +1 more source
Future options for disease intervention: important advances in phosphodiesterase 4 inhibitors
European Respiratory Review, 2007 Current drug treatments for chronic obstructive pulmonary disease (COPD) focus on managing symptoms of the disease and include short- and long-acting beta2-agonists, anticholinergic agents (ipratroprium, tiotropium), methylxanthines (theophylline) and ...
R. A. McIvor
doaj
Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex. [PDF]
, 2018 Numerous types of inhibitory neurons sculpt the performance of human neocortical circuits, with each type exhibiting a constellation of subcellular phenotypic features in support of its specialized functions.
Chang, Edward F +9 more
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