Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia
Glia, Volume 73, Issue 10, Page 2025-2034, October 2025.Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc +10 more
wiley +1 more source
Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm. [PDF]
Proc Natl Acad Sci U S A, 2021 Zhang C +10 more
europepmc +1 more source
Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors. [PDF]
, 1982 We have measured the levels of 3',5'-guanosine monophosphate (cyclic GMP) in isolated retinas from toad to investigate their correlation to the opening and closing of the light-dependent permeability of photoreceptors. When Ca2+-induced changes in cyclic
Fain, GL, Woodruff, ML
core
What Does Iron Mean to an Oligodendrocyte?
Glia, Volume 73, Issue 9, Page 1784-1804, September 2025.Main Points Iron is essential for oligodendrocyte (OL) biology and myelin production, with deficiencies leading to severe neurological impairments. Understanding iron trafficking in OLs is crucial for developing treatments for dysmyelinating conditions. ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions.
Quinn W. Wade, James R. Connor
wiley +1 more source
Moracin M derivative targeting PDE4 for the treatment of psoriasis
Acta Materia MedicaPhosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity with PDE4 inhibitors increases intracellular cAMP levels
Liru Chen +8 more
doaj +1 more source
An update of cyclic nucleotide phosphodiesterase as a target for cardiac diseases. [PDF]
Expert Opin Drug Discov, 2021 Chen S, Yan C.
europepmc +1 more source
On the role of cyclic nucleotides in the transmitter choice made by cultured sympathetic neurons [PDF]
, 1981 Previous investigations have established that electrical activity or chronic depolarization influences the development of neonatal rat sympathetic neurons in dissociated cell culture.
Patterson, Paul H., Walicke, Patricia A.
core +1 more source
Primary Progressive Multiple Sclerosis: New Therapeutic Approaches
Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi +8 more
wiley +1 more source
BMC Medical Genetics, 2009 Background 2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP), one of the promising candidate genes for schizophrenia, plays a key part in the oligodendrocyte function and in myelination. The present study aims to investigate the relationship between CNP
Zhang Zhao +11 more
doaj +1 more source
The Effects of Cyclic Nucleotide Phosphodiesterase Inhibitors on Ejaculated Porcine Spermatozoan Metabolism1 [PDF]
, 1973 David L. Garbers +3 more
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