Acta Physiologica, Volume 241, Issue 8, August 2025.ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth +2 more
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Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.ABSTRACT The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short‐term control of coronary blood flow is achieved via alterations in coronary microvascular tone, whereas long‐term control of coronary flow also involves remodelling of the coronary microvasculature ...
Oana Sorop +3 more
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The Multiple Roles of Myelin Protein Genes During the Development of the Oligodendrocyte
ASN Neuro, 2009 It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2′, 3′-cyclic nucleotide 3′-
Daniel Fulton +2 more
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Effect of Ca2+ on the stability of the protein activator of cyclic nucleotide phosphodiesterase [PDF]
, 1975 openalex +1 more source
Proteomic associations with fluctuation and long‐term changes in BMI: A 40‐year follow‐up study
Diabetes, Obesity and Metabolism, Volume 27, Issue 8, Page 4192-4202, August 2025.Abstract Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention‐based, offering limited insight into proteomic associations with long‐term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time.
Alvaro Obeso +6 more
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Detergent activation and solubilization of 2′:3′-cyclic nucleotide 3′-phosphodiesterase from isolated myelin and c6 cells [PDF]
, 1979 Neil R. Sims +2 more
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Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages
Applied SciencesCyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation.
Simona Todisco +8 more
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Long-term effects of a high glucose concentration on cyclic nucleotide phosphodiesterase activity in mouse pancreatic islets maintained in tissue culture [PDF]
, 1976 Christian Berne, Arne Andersson
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Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]
, 1994 Forssmann, W. G. +6 more
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Future options for disease intervention: important advances in phosphodiesterase 4 inhibitors
European Respiratory Review, 2007 Current drug treatments for chronic obstructive pulmonary disease (COPD) focus on managing symptoms of the disease and include short- and long-acting beta2-agonists, anticholinergic agents (ipratroprium, tiotropium), methylxanthines (theophylline) and ...
R. A. McIvor
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