Results 151 to 160 of about 42,131 (286)

Cyclic nucleotide phosphodiesterases as drug targets

open access: yesPharmacological Reviews
Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick
Michy P. Kelly   +28 more
openaire   +2 more sources

A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction. [PDF]

open access: yesCirculation, 2020
Chen S   +7 more
europepmc   +1 more source

Role of phosphodiesterase 5 in synaptic plasticity and memory

open access: yesNeuropsychiatric Disease and Treatment, 2008
Daniela Puzzo1,2, Salvatore Sapienza1, Ottavio Arancio2, Agostino Palmeri11Dept of Physiological Sciences, University of Catania, Catania, Italy; 2Dept of Pathology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain ...
Daniela Puzzo   +3 more
doaj  

Cyclic AMP modulation of ion transport across frog retinal pigment epithelium. Measurements in the short-circuit state. [PDF]

open access: yes, 1984
In the frog retinal pigment epithelium (RPE), the cellular levels of cyclic AMP (cAMP) were measured in control conditions and after treatment with substances that are known to inhibit phosphodiesterase (PDE) activity (isobutyl-1-methylxanthine, SQ65442)
Farber, D, Miller, S
core  

Isolation of Nuclei from Physarum flavicomum: Demonstration of Nuclear Cyclic Acid AMP Phosphodiesterase [PDF]

open access: yes, 1986
Cyclic AMP phosphodiesterase activity in the nucleus of the myxomycete Physarum flavicomum was demonstrated by cytochemical staining utilizing electron microscopy and by enzymatic assays with tritiated cyclic AMP as the substrate.
Bean, Judith A.   +2 more
core   +2 more sources

Home - About - Disclaimer - Privacy