Results 171 to 180 of about 76,071 (304)

Future options for disease intervention: important advances in phosphodiesterase 4 inhibitors

European Respiratory Review, 2007
Current drug treatments for chronic obstructive pulmonary disease (COPD) focus on managing symptoms of the disease and include short- and long-acting beta2-agonists, anticholinergic agents (ipratroprium, tiotropium), methylxanthines (theophylline) and ...
R. A. McIvor
doaj  

Response by Chen and Yan to Letter Regarding Article, "A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction". [PDF]

Circulation, 2020
Chen S, Yan C.
europepmc   +1 more source

Long-term effects of a high glucose concentration on cyclic nucleotide phosphodiesterase activity in mouse pancreatic islets maintained in tissue culture [PDF]

, 1976
Christian Berne, Arne Andersson
openalex   +1 more source

Cyclic nucleotide phosphodiesterases as drug targets

Pharmacological Reviews
Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick
Michy P. Kelly, Viacheslav O. Nikolaev, Leila Gobejishvili, Claire Lugnier, Christian Hesslinger, Peter Nickolaus, David A. Kass, Walma Pereira de Vasconcelos, Rodolphe Fischmeister, Stefan Brocke, Paul M. Epstein, Gary A. Piazza, Adam B. Keeton, Gang Zhou, Mohammad Abdel-Halim, Ashraf H. Abadi, George S. Baillie, Mark A. Giembycz, Graeme Bolger, Gretchen Snyder, Kjetil Tasken, Nathaniel E.B. Saidu, Martina Schmidt, Manuela Zaccolo, Ralph T. Schermuly, Hengming Ke, Rick H. Cote, Soroush Mohammadi Jouabadi, Anton J.M. Roks   +28 more
openaire   +2 more sources

Letter to the Editor: Resolution of the Presence of Multiple Forms of the Cyclic Nucleotide Phosphodiesterases (PDE) in Normal and Reye's Syndrome Liver [PDF]

, 1979
Ellen S. Kang
openalex   +1 more source

A Cyclic 3', 5'-Nucleotide Phosphodiesterase from Heart with Specificity for Uridine 3', 5'-Phosphate

, 1965
Joel G. Hardman, Earl W. Sutherland
openalex   +1 more source

Calcium-dependent 3‘:5‘-cyclic nucleotide phosphodiesterase. Inhibition of basal activity at physiological levels of potassium ions.

, 1978
Craig W. Davis, John W. Daly
openalex   +1 more source

Role of phosphodiesterase 5 in synaptic plasticity and memory

Neuropsychiatric Disease and Treatment, 2008
Daniela Puzzo1,2, Salvatore Sapienza1, Ottavio Arancio2, Agostino Palmeri11Dept of Physiological Sciences, University of Catania, Catania, Italy; 2Dept of Pathology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain ...
Daniela Puzzo, Salvatore Sapienza, Ottavio Arancio, Agostino Palmeri   +3 more
doaj  

Cyclic AMP modulation of ion transport across frog retinal pigment epithelium. Measurements in the short-circuit state. [PDF]

, 1984
In the frog retinal pigment epithelium (RPE), the cellular levels of cyclic AMP (cAMP) were measured in control conditions and after treatment with substances that are known to inhibit phosphodiesterase (PDE) activity (isobutyl-1-methylxanthine, SQ65442)
Farber, D, Miller, S
core  

The myelin membrane-associated enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase: on a highway to structure and function

Neuroscience Bulletin, 2014
A. Raasakka, P. Kursula
semanticscholar   +1 more source