Results 11 to 20 of about 220 (99)

ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1

Molecules, 2019
Ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1) was identified several decades ago as a type II transmembrane glycoprotein with nucleotide pyrophosphatase and phosphodiesterase enzymatic activities, critical for purinergic signaling. Recently,
Kenneth I. Onyedibe, Modi Wang, Herman O. Sintim   +2 more
doaj   +1 more source

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection

Gut Microbes, 2020
Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) has a continuing impact on residents and travelers in underdeveloped countries. Both heat-labile (LT) and heat-stable (ST) enterotoxins contribute to pathophysiology via induction of cyclic ...
Jennifer Foulke-Abel, Huimin Yu, Laxmi Sunuwar, Ruxian Lin, James M. Fleckenstein, James B. Kaper, Mark Donowitz   +6 more
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Streptococcus pyogenes c-di-AMP phosphodiesterase, GdpP, influences SpeB processing and virulence. [PDF]

PLoS ONE, 2013
Small cyclic nucleotide derivatives are employed as second messengers by both prokaryotes and eukaryotes to regulate diverse cellular processes responding to various signals. In bacteria, c-di-AMP has been discovered most recently, and some Gram-positive
Kyu Hong Cho, Song Ok Kang
doaj   +1 more source

Reversal of spatial memory impairment by phosphodiesterase 3 inhibitor cilostazol is associated with reduced neuroinflammation and increased cerebral glucose uptake in aged male mice

Frontiers in Pharmacology, 2022
The nucleotide second messenger 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) mediate fundamental functions of the brain, including learning and memory.
Shuichi Yanai, Tetsuro Tago, Jun Toyohara, Tomoko Arasaki, Shogo Endo   +4 more
doaj   +1 more source

Two phosphodiesterases from Ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases

Frontiers in Microbiology, 2010
The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi.
Charu eAgarwal, David J Schultz, Michael H Perlin   +2 more
doaj   +1 more source

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate

Frontiers in Physiology, 2022
Introduction: Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiovascular dysfunction, which could lead to shock. Current guidelines do not recommend any pharmacological treatment at core temperatures below 30°C, due ...
Adrina Kalasho Kuzmiszyn, Adrina Kalasho Kuzmiszyn, Adrina Kalasho Kuzmiszyn, Anders Lund Selli, Natalia Smaglyukova, Timofei Kondratiev, Ole-Martin Fuskevåg, Roy Andre Lyså, Aina Westrheim Ravna, Torkjel Tveita, Torkjel Tveita, Georg Sager, Erik Sveberg Dietrichs, Erik Sveberg Dietrichs   +13 more
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Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening

Frontiers in Chemistry, 2021
Several members of the 3′,5′-cyclic nucleotide phosphodiesterase (PDE) family play an essential role in cellular processes, which has labeled them as interesting targets for various diseases. The parasitic protozoan Trypanosoma brucei, causative agent of
Erik de Heuvel, Albert J. Kooistra, Ewald Edink, Sjors van Klaveren, Jeffrey Stuijt, Tiffany van der Meer, Payman Sadek, Dorien Mabille, Guy Caljon, Louis Maes, Marco Siderius, Iwan J. P. de Esch, Geert Jan Sterk, Rob Leurs   +13 more
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Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.

PLoS Biology, 2019
Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation. Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechanisms by which cyclic AMP (cAMP) is regulated remain ...
Christian Flueck, Laura G Drought, Andrew Jones, Avnish Patel, Abigail J Perrin, Eloise M Walker, Stephanie D Nofal, Ambrosius P Snijders, Michael J Blackman, David A Baker   +9 more
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Cyclic nucleotide phosphodiesterases in pancreatic islets [PDF]

Diabetologia, 2003
Cyclic nucleotide phosphodiesterases (PDEs) comprise a family of enzymes (PDE1-PDE11) which hydrolyse cyclic AMP and cyclic GMP to their biologically inactive 5' derivatives. Cyclic AMP is an important physiological amplifier of glucose-induced insulin secretion.
Pyne, N J, Furman, B L
openaire   +3 more sources

The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells

Computational and Structural Biotechnology Journal, 2020
Cyclic nucleotide signaling is pivotal to the asexual reproduction of Toxoplasma gondii, however little do we know about the phosphodiesterase enzymes in this widespread obligate intracellular parasite.
Kim Chi Vo, Özlem Günay-Esiyok, Nicolas Liem, Nishith Gupta   +3 more
doaj   +1 more source