Results 11 to 20 of about 42,131 (286)
Advances in targeting cyclic nucleotide phosphodiesterases
Nature Reviews Drug Discovery, 2014 Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling pathways and, consequently, myriad biological responses in health and disease.
Faiyaz Ahmad +5 more
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Phosphodiesterases and Cyclic Nucleotide Signaling in Endocrine Cells [PDF]
Molecular Endocrinology, 2000 The discovery of cyclic nucleotides as second messengers has paved the way to much of what we know about signal transduction and the mechanisms of hormone action. Even though other signaling pathways activated by growth factors are the focus of much attention, cyclic nucleotides remain among the most important players in hormone action. When envisioned
Marco Conti
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Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation. [PDF]
PLoS ONE, 2012 The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is a highly abundant membrane-associated enzyme in the myelin sheath of the vertebrate nervous system.
Matti Myllykoski +3 more
doaj +1 more source
Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. [PDF]
PLoS ONE, 2011 Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for regulating smooth muscle tone, platelet activation, nociception and memory formation.
Jeong Joo Kim +10 more
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A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors
Frontiers in Chemistry, 2023 Phosphodiesterase type 5 (PDE5), a cyclic nucleotide phosphodiesterase, controls the duration of the cyclic guanosine monophosphate (cGMP) signal by hydrolyzing cGMP to GMP.
Yufeng Ma +9 more
doaj +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
Cells, 2022 Dopamine and other neurotransmitters have the potential to induce neuroplasticity in the striatum via gene regulation. Dopamine receptor-mediated gene regulation relies on second messenger cascades that involve cyclic nucleotides to relay signaling from ...
Ryan Bonate +6 more
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Cyclic nucleotide phosphodiesterases in pancreatic islets [PDF]
Diabetologia, 2003 Cyclic nucleotide phosphodiesterases (PDEs) comprise a family of enzymes (PDE1-PDE11) which hydrolyse cyclic AMP and cyclic GMP to their biologically inactive 5' derivatives. Cyclic AMP is an important physiological amplifier of glucose-induced insulin secretion.
Pyne, N J, Furman, B L
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Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. [PDF]
PLoS ONE, 2011 BACKGROUND: Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many cell types. This cyclic nucleotide plays a key role in signal transduction in a wide variety of cellular responses.
Jose A Morales-Garcia +7 more
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The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected].. [PDF]
PLoS ONE, 2013 Adenosine 3', 5'-cyclic monophosphate (cAMP) and guanosine 3', 5'-cyclic monophosphate (cGMP) are well-studied second messengers that transmit extracellular signals into mammalian cells, with conserved functions in various other species such as ...
Ulrike Beckert +6 more
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